We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus-based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increased stability of the vaccines, but specific vesicular stomatitis virus-based vaccines will each require extensive analysis to optimize stabilizing formulations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060439 | PMC |
| http://dx.doi.org/10.3201/eid3005.231248 | DOI Listing |
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