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| http://dx.doi.org/10.1242/dmm.050815 | DOI Listing |
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The mitochondrial function of peripheral blood mononuclear cells in frail older patients.
Exp Gerontol
November 2024
Division of Geriatric Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, China. Electronic address:
Article Synopsis
- Frailty is linked to increased health risks in older adults, but diagnosing it is complicated due to varied symptoms and underlying causes, prompting a study to explore mitochondrial function as a potential biomarker for frailty.* -
- In a study of 393 participants aged 25-100, researchers assessed frailty using the physical frailty phenotype scale and analyzed various mitochondrial functions and morphology in peripheral blood mononuclear cells (PBMCs).* -
- Results showed significant differences in mitochondrial characteristics and functions between frail and non-frail older adults, highlighting potential correlations between mitochondrial health and frailty status, particularly regarding factors like mtDNA copy number and respiratory function.*
Author Correction: Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons.
Cell Death Dis
September 2024
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, 215006, Suzhou, Jiangsu Province, China.
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome.
JCI Insight
June 2024
Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Article Synopsis
- Autosomal dominant optic atrophy plus (ADOA+) is a condition featuring optic nerve damage and various degenerative neurological symptoms, with no effective treatments available yet.
- The study identified a new genetic variant in the OPA1 gene that leads to mitochondrial dysfunction through a series of cellular experiments.
- The mitochondrial division inhibitor Mdivi-1 showed potential in reversing the negative effects of OPA1 impairment by improving mitochondrial function, suggesting it as a promising treatment strategy for ADOA+.
Nicotinamide Mononucleotide and Nicotinamide Riboside Reverse Ovarian Aging in Rats Via Rebalancing Mitochondrial Fission and Fusion Mechanisms.
Pharm Res
May 2024
Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Purpose: This study examined the effects of nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) on folliculogenesis and mitochondrial dynamics (fission and fusion mechanisms) in ovaries of middle-aged female rats.
Methods: Experimental groups were young, middle-aged (control), middle-aged + NMN and middle-aged + NR. NMN was administered at a concentration of 500 mg/kg intraperitoneally but NR at a concentration of 200 mg/kg by gavage.
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