AI Article Synopsis
- The structural transitions in macromolecules can destabilize them when temperatures increase or decrease.
- DNA origami can show these heat capacity changes effectively.
- They allow researchers to observe cold denaturation by focusing on sensitive parts of their complex structure.
Article Abstract
The coupling of structural transitions to heat capacity changes leads to destabilization of macromolecules at both elevated and lowered temperatures. DNA origami not only exhibit this property but also provide a nanoscopic observable of cold denaturation processes by directing intramolecular strain to the most sensitive elements within their hierarchical architecture.
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| http://dx.doi.org/10.1039/d3cc05985e | DOI Listing |
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