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Safety and efficacy of satralizumab in patients with generalised myasthenia gravis (LUMINESCE): a randomised, double-blind, multicentre, placebo-controlled phase 3 trial.
Lancet Neurol
February 2025
Department of Neurology, International University of Health and Welfare, Narita, Japan.
Background: Evidence from preclinical studies suggests that IL-6 signalling has the potential to modulate immunopathogenic mechanisms upstream of autoantibody effector mechanisms in patients with generalised myasthenia gravis. We aimed to assess the safety and efficacy of satralizumab, a humanised monoclonal antibody targeting the IL-6 receptor, in patients with generalised myasthenia gravis.
Methods: LUMINESCE was a randomised, double-blind, placebo-controlled, multicentre, phase 3 study at 105 sites, including hospitals and clinics, globally.
Coping after the COVID-19 pandemic: nurses' learning intent and implications for the workforce and education.
Br J Nurs
January 2025
Professor, Department of Nursing, Beaver College of Health Sciences, Appalachian State University, Boone, North Carolina, USA.
Background/aim: Addressing the critical global shortage of nurses requires an understanding of how a global pandemic reshaped nurses' motivations and intentions toward education. This study aimed to describe COVID-19's impact on nurses' intent to pursue additional education.
Method: This descriptive study, based in North Carolina in the USA, used content analysis with an inductive approach to examine the responses of nurses to one open-ended question in a large quantitative workforce survey: how has COVID-19 influenced your plans for future education? Responses were coded with counts and organised into themes and subthemes.
The effects of volunteering on loneliness among lonely older adults: the HEAL-HOA dual randomised controlled trial.
Lancet Healthy Longev
January 2025
Department of Social Sciences and Policy Studies, The Education University of Hong Kong, Tai Po, Hong Kong Special Administrative Region, China.
Background: Previous randomised controlled trials have largely relied on self-reported volunteer work to assess the effects of volunteering and have rarely provided structured volunteering activities during the intervention period. The present study aimed to investigate the effects of social volunteering work over 12 months on loneliness among older adults during the COVID-19 pandemic.
Methods: A dual randomised controlled trial was done in Hong Kong to investigate the long-term effects of telephone-delivered psychosocial interventions by older Chinese volunteers who were screened as lonely, for older adult recipients who had low income, lived alone, felt lonely, and were digitally excluded.
Moderating role of age in the relationship between ingroup range and intention to help during the COVID-19 pandemic.
PLoS One
January 2025
Department of Psychology, Sungshin Women's University, Seongbuk-gu, Seoul, Republic of Korea.
This study explored the relationship between the ingroup range of individuals and their willingness to assist various social groups during the COVID-19 pandemic and whether or not age moderates this relationship. A total of 291 South Koreans (Mage = 31.91 years, SD = 11.
View Article and Find Full Text PDFSeasonal Influenza Vaccination Uptake Among Australian Healthcare Professionals: An Archetype for Success.
Vaccines (Basel)
January 2025
Faculty of Health, University of Canberra, Bruce, ACT 2617, Australia.
Background/objectives: Qualitative research suggests there may be identifiable characteristics that form a health professional (HCP) archetype associated with habitual seasonal influenza vaccination (SIV). However, the validity of this archetype requires further investigation, ideally within a theoretical framework that can elucidate this association and its generalisability to other vaccines. This study aims to confirm key HCP archetype characteristics associated with SIV, as informed by prior qualitative research findings, and test the generalisability of the association between this archetype and SIV to COVID-19 vaccine acceptance.
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