Carcinosarcoma of the esophagus constitutes only 0.5%-2.8% of all malignant esophageal cancers. It is identified by the presence of both carcinomatous and sarcomatous components. A clear regimen of treatment has not been established due to the limited understanding of the disease. We present a case of carcinosarcoma of the esophagus with rapid recurrence and invasion to the intrathoracic cavity only 6 weeks after esophagectomy. Carcinosarcoma carries a poor prognosis, as it has a late tendency of hematogenous spread with a high growth rate.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045243PMC
http://dx.doi.org/10.1093/jscr/rjae236DOI Listing

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Article Synopsis
  • - Carcinosarcoma is a rare type of esophageal cancer, making up just 0.27-2.8% of all malignant esophageal tumors, and the study focused on its clinical traits and treatment outcomes from 16 patients who had surgical interventions.
  • - Most carcinosarcoma cases were found in the middle and lower esophagus and showed various growth patterns; lymph node metastasis was present in half of the patients, with certain pathological features linked to survival rates.
  • - The study concluded that carcinosarcoma has a distinct biphasic histological pattern that is important for diagnosis, but it may be tricky to identify due to the often subtle presence of tumor components in small biopsies.
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Carcinosarcoma of the esophagus constitutes only 0.5%-2.8% of all malignant esophageal cancers.

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Sarcomatoid carcinoma of the esophagus, a mixed tumor comprising both carcinomatous and sarcomatoid components and known as carcinosarcoma, is a rare malignancy. Clinically and radiologically, it presents like other esophageal cancers. Here we discuss the case of a 69-year-old male patient with sarcomatoid carcinoma of the esophagus who developed Stevens-Johnson syndrome (SJS) after chemotherapy with carboplatin and paclitaxel.

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Esophageal cancer is common worldwide, including in Japan, and its major histological subtype is squamous cell carcinoma. However, there are some rare esophageal cancers, including neuroendocrine neoplasm, gastrointestinal stromal tumor, carcinosarcoma and malignant melanoma. The biological and clinical features of these cancers differ from those of esophageal squamous cell carcinoma.

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Esophageal carcinosarcoma is an uncommon histologic variant of esophageal malignancy, occurring in approximately 0.5% to 2.8% of patients.

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