AI Article Synopsis
- - Hypertensive disorder of pregnancy (HDP) affects 10% of pregnancies globally and includes conditions like chronic hypertension and preeclampsia, leading to serious health risks for both mothers and infants.
- - A study examining brachial artery flow-mediated dilation (BAFMD) showed that women with HDP had significantly lower BAFMD compared to normotensive pregnant and nonpregnant women, though no major differences were found between HDP subgroups.
- - While BAFMD decreased with gestational age, it proved to be a poor indicator for HDP, with body mass index (BMI) identified as a better predictor for the condition.
Article Abstract
Background: Hypertensive disorder of pregnancy (HDP) comprise chronic hypertension, gestational hypertension, preeclampsia/eclampsia, and preeclampsia superimposed on chronic hypertension. HDP complicate up to 10% of pregnancies worldwide and carry significant risks of maternal and perinatal morbidity and mortality. The aim of this study was to evaluate the derangement and characteristics of brachial artery flow-mediated dilation (BAFMD) in women with HDP.
Methods: The BAFMD of the right brachial artery of 80 women with HDP (pregnant HDP), 80 normotensive pregnant women (pregnant non-HDP), and 80 healthy nonpregnant women (nonpregnant controls) was evaluated with B-mode ultrasound. The age, blood pressure, body mass index (BMI), brachial artery diameter, and BAFMD of the participants were compared. ≤ 0.05 was statistically significant.
Results: The pregnant HDP group had significantly lower mean BAFMD compared to pregnant non-HDP and nonpregnant controls (6.9% ± 2.53% vs. 8.32% ± 3.4% vs. 9.4% ± 2.68%; < 0.001). There was no significant difference between the mean BAFMD of the pregnant HDP subgroups: preeclampsia (5.81% ± 1.7%) versus gestational hypertension (6.43% ± 3.02%); = 0.57. BAFMD diminished with advancing gestational age in both the pregnant HDP and pregnant non-HDP groups. On regression analysis, BAFMD was a poor marker for HDP, while BMI was an independent predictor for HDP.
Conclusion: Even though HDP were associated with significantly diminished BAFMD, it was not a good marker for HDP.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11040488 | PMC |
| http://dx.doi.org/10.4103/jmu.jmu_10_23 | DOI Listing |
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