Cardiovascular risk burden and disability: findings from the International Mobility in Aging Study (IMIAS).

J Geriatr Cardiol

Research Group in Geriatrics and Gerontology, Faculty of Health Sciences, Universidad de Caldas, Manizales, Colombia.

Published: March 2024

AI Article Synopsis

  • The study investigates how cardiovascular risk, measured by the Framingham general cardiovascular disease risk score (FGCRS), is linked to physical function decline in older adults over time.
  • Researchers analyzed data from 1,219 healthy participants over several years, using the Short Physical Performance Battery (SPPB) to assess physical limitations.
  • Findings indicate that higher FGCRS correlates with reduced physical performance, particularly in walking abilities, while factors like education and living conditions can mitigate the risk of disability.

Article Abstract

Background: The association of cardiovascular risk burden with disability is unclear. We examined the association between trajectories of the Framingham general cardiovascular disease risk score (FGCRS) with the trajectories of limitations of physical function in older adults.

Methods: A total of 1219 participants with no disabilities from the International Mobility in Aging Study (IMIAS) study who had up to three repeated measures of FGCRS between 2012-2016 and without a history of stroke or coronary heart disease at baseline and follow-up were included. FGCRS at baseline was assessed and categorized into tertiles. Physical function was evaluated with the Short Physical Performance Battery (SPPB). The data were analyzed using linear mixed-effects models.

Results: At baseline, FGCRS ranged between 3-94 (mean score: 24 ± 15.8), participants were 32 (2.6%), 502 (41.2%) and 685 (56.2%) in lowest, middle, and highest tertiles, respectively. In the trajectories of limitations of physical function, the lowest FGCRS had no differences, while the middle and highest had a decrease in physical performance between 2012-2014 ( = 0.0001). Age, being female, living in Andes Mountains, having middle and highest FGCRS, higher alcohol consumption, being obese, lack of exercise and cognitive impairment increase the probability of disability ( < 0.05). Alternatively, living in more developed regions and having a higher educational level reduced the probability of disability during the follow-up time ( < 0.05).

Conclusions: Higher cardiovascular risk burden is associated with decreased physical performance, especially in gait. Results suggest SPPB may provide a measure of cardiovascular health in older adults.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11040056PMC
http://dx.doi.org/10.26599/1671-5411.2024.03.002DOI Listing

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