Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD) is an autoimmune disease responsible for demyelination of the central nervous system that can occur in adults or children. Overlapping phenotypes between MOGAD, multiple sclerosis (MS) and neuromyelitis optica spectrum disease (NMOSD) have been described. The diagnostic criteria for MOGAD were proposed by a panel of international experts and published in 2023. Defining clinical, biological and imaging characteristics specific to this entity helps to improve diagnostic specificity. In this article, we present the clinical characteristics suggestive of MOGAD and discuss the importance of the antibody detection method and therapeutic management.
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| http://dx.doi.org/10.53738/REVMED.2024.20.871.828 | DOI Listing |
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View Article and Find Full Text PDFIncreased Intracranial Pressure in Myelin-Oligodendrocyte Glycoprotein Antibody-Associated Disease.
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Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA.
Objectives: To assess characteristics of increased intracranial pressure (ICP) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).
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Do specific myelin autoantibodies and increased cerebral dopamine neurotrophic factor in the context of inflammation predict the diagnosis of attention deficit hyperactivity disorder in medication-free children?
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Department of Radiology, Konya City Hospital, Karatay-Konya 42020, Turkey. Electronic address:
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- Researchers included 141 ADHD children aged 8-14 and 135 typical controls, measuring protein levels using specific assays and assessing behaviors with standardized scales.
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Instituto do Cérebro, Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address:
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The Varying Faces of MOGAD: A Case Series.
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Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated disease (MOGAD) is an immune mediated demyelinating disorder initially described as a subtype of neuromyelitis optica spectrum disorder with antibodies against MOG. Recently, it has been described as a separate disease entity with unique clinical and radiological features. We herein report the clinical details of eight MOG-IgG-positive patients to highlight the peculiar and varied clinical and radiological features of this condition.
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