AI Article Synopsis
- Fetal cortical boundaries can be affected by morphogenetic stress, which impacts microglia development.
- This altered state of microglia is similar to that seen after birth and is linked to brain structure, specifically axon-tracts.
- One key function of these microglia is to prevent cavitary lesions by regulating the phagocytosis of fibronectin 1 through a pathway involving Spp1.
Article Abstract
Lawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1.
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| http://dx.doi.org/10.1016/j.it.2024.04.005 | DOI Listing |
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