AI Article Synopsis
- Asthma is a complex condition marked by chronic inflammation in the airways, reversible airflow issues, and structural changes in the airways, with eosinophil peroxidase (EPX) being a key protein involved.
- The study found that higher levels of EPX and ADAM33 in asthma patients are associated with poorer lung function and increased levels of the inflammatory marker IL-5.
- EPX promotes changes in airway cells (known as epithelial-mesenchymal transition) that contribute to asthma symptoms, and inhibiting a specific pathway (PI3K) can enhance the understanding of EPX's role, potentially leading to new treatments for airway remodeling in asthma.
Article Abstract
Asthma is a heterogeneous disease characterized by chronic airway inflammation, reversible airflow limitation, and airway remodeling. Eosinophil peroxidase (EPX) is the most abundant secondary granule protein unique to activated eosinophils. In this study, we aimed to illustrate the effect of EPX on the epithelial-mesenchymal transition (EMT) in BEAS-2B cells. Our research found that both EPX and ADAM33 were negatively correlated with FEV1/FVC and FEV1%pred, and positively correlated with IL-5 levels. Asthma patients had relatively higher levels of ADAM33 and EPX compared to the healthy control group. The expression of TSLP, TGF-β1 and ADAM33 in the EPX intervention group was significantly higher. Moreover, EPX could promote the proliferation, migration and EMT of BEAS-2B cells, and the effect of EPX on various factors was significantly improved by the PI3K inhibitor LY294002. The findings from this study could potentially offer a novel therapeutic target for addressing airway remodeling in bronchial asthma, particularly focusing on EMT.
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| http://dx.doi.org/10.1016/j.clim.2024.110228 | DOI Listing |
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