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Hearing loss occurs prior to thrombocytopenia in both mice and humans with DFNA1.
FASEB J
January 2025
Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan.
DFNA1 (deafness, nonsyndromic autosomal dominant 1), initially identified as nonsyndromic sensorineural hearing loss, has been associated with an additional symptom: macrothrombocytopenia. However, the timing of the onset of hearing loss (HL) and thrombocytopenia has not been investigated, leaving it unclear which occurs earlier. Here, we generated a knock-in (KI) DFNA1 mouse model, diaphanous-related formin 1 (DIA1), in which Aequorea coerulescens green fluorescent protein (AcGFP)-tagged human DIA1(p.
View Article and Find Full Text PDFSingle-Cell RNA Sequencing Reveals the Cellular Origin and Evolution of Small-Cell Neuroendocrine Carcinoma of the Cervix.
J Med Virol
January 2025
Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, P. R. China.
Small-cell neuroendocrine cancer (SCNEC) of the uterine cervix is an exceedingly rare, highly aggressive tumor with an extremely poor prognosis. The cellular heterogeneity, origin, and tumorigenesis trajectories of SCNEC of the cervix remain largely unclear. We performed single-cell RNA sequencing and whole-exome sequencing on tumor tissues and adjacent normal cervical tissues from two patients diagnosed with SCNEC of the cervix.
View Article and Find Full Text PDFEfficient and accurate tobacco leaf maturity detection: an improved YOLOv10 model with DCNv3 and efficient local attention integration.
Front Plant Sci
January 2025
College of Agricultural Equipment Engineering, Henan University of Science and Technology, Luoyang, Henan, China.
The precise determination of tobacco leaf maturity is pivotal for safeguarding the taste and quality of tobacco products, augmenting the financial gains of tobacco growers, and propelling the industry's sustainable progression. This research addresses the inherent subjectivity and variability in conventional maturity evaluation techniques reliant on human expertise by introducing an innovative YOLOv10-based method for tobacco leaf maturity detection. This technique facilitates a rapid and non-invasive assessment of leaf maturity, significantly elevating the accuracy and efficiency of tobacco leaf quality evaluation.
View Article and Find Full Text PDFSome Challenging Questions About Outcomes in Children With Cochlear Implants.
Perspect ASHA Spec Interest Groups
December 2024
DeVault Otologic Research Laboratory, Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis.
Purpose: Cochlear implants (CIs) have improved the quality of life for many children with severe-to-profound sensorineural hearing loss. Despite the reported CI benefits of improved speech recognition, speech intelligibility, and spoken language processing, large individual differences in speech and language outcomes are still consistently reported in the literature. The enormous variability in CI outcomes has made it challenging to predict which children may be at high risk for limited benefits and how potential risk factors can be improved with interventions.
View Article and Find Full Text PDFGlobal Research Trends in Cervical Cancer Survival in the Last Two Decades: A Bibliometric Analysis.
Malays J Med Sci
December 2024
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Cervical cancer poses a significant challenge to global health, particularly in low- and middle-income countries. Tracking the survival rates of cancer patients through data gathered by population-based cancer registries constitutes a crucial aspect of cancer management. In recent years, attention within bibliometric studies has been directed towards examining the correlation between inflammation and radiotherapy in cervical cancer.
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