Translocator protein (TSPO) is a biomarker of Zika virus (ZIKV) infection-associated neuroinflammation.

Emerg Microbes Infect

Laboratory for Translational and Molecular Imaging (LTMI), Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.

Published: December 2024

Zika is a systemic inflammatory disease caused by infection with Zika virus (ZIKV). ZIKV infection in adults is associated with encephalitis marked by elevated expression of pro-inflammatory cytokines and chemokines, as well as increased brain infiltration of immune cells. In this study, we demonstrate that ZIKV encephalitis in a mouse infection model exhibits increased brain TSPO expression. TSPO expression on brain-resident and infiltrating immune cells in ZIKV infection correlates with disease and inflammation status in the brain. Brain TSPO expression can also be sensitively detected and using radioactive small molecule probes that specifically bind to TSPO, such as [H]PK11195. TSPO expression on brain-resident and infiltrating immune cells is a biomarker of ZIKV neuroinflammation, which can also be a general biomarker of acute viral neuroinflammatory disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132733PMC
http://dx.doi.org/10.1080/22221751.2024.2348528DOI Listing

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