AI Article Synopsis
- Human enteroviruses include over 300 genotypes, but cross protective immunity among them is not seen in humans, despite previous findings with poliovirus.
- Researchers tested whether immunization in mice and baboons with inactivated poliovirus or enterovirus VLPs could produce antibodies that recognize enterovirus D68 or A71.
- The results showed that mice produced only specific antibodies to the antigens they were given, and baboons also did not generate neutralizing antibodies against D68 or A71, highlighting the need for multivalent vaccines to protect vulnerable populations.
Article Abstract
Human enteroviruses are the most common human pathogen with over 300 distinct genotypes. Previous work with poliovirus has suggested that it is possible to generate antibody responses in humans and animals that can recognize members of multiple enterovirus species. However, cross protective immunity across multiple enteroviruses is not observed epidemiologically in humans. Here we investigated whether immunization of mice or baboons with inactivated poliovirus or enterovirus virus-like-particles (VLPs) vaccines generates antibody responses that can recognize enterovirus D68 or A71. We found that mice only generated antibodies specific for the antigen they were immunized with, and repeated immunization failed to generate cross-reactive antibody responses as measured by both ELISA and neutralization assay. Immunization of baboons with IPV failed to generate neutralizing antibody responses against enterovirus D68 or A71. These results suggest that a multivalent approach to enterovirus vaccination is necessary to protect against enterovirus disease in vulnerable populations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045126 | PMC |
| http://dx.doi.org/10.1371/journal.ppat.1012159 | DOI Listing |
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