Background: In Nigeria, the use of psychoactive substances has reached an epidemic proportion while substance use prevention remains inadequate or unavailable.

Methods: Cross-sectional data from 300 Junior Secondary School students in Imo state were analyzed to evaluate the unmet need for school-based substance use prevention strategies among secondary school students in Orlu, Imo state. Information was collected using a structured questionnaire.

Results: Substance use was common with easy access to psychoactive substances for young people. There was a perceived need for substance use prevention strategies in their school with most students lacking access to basic preventive strategies.

Conclusion: Though there was a high need for preventive strategies for substance abuse among secondary school students in Orlu, few strategies were in place to meet the needs of the students.

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