The study was designed to develop and analyze curcumin nanoparticles. Curcumin nanoparticles were formulated and evaluated. Their efficacy in protecting against brain damage was investigated in a rat model of ischemic stroke, considering motor function, muscle strength and antioxidant enzyme activity. Curcumin nanoparticles displayed a zeta potential of -55 ± 13.5 mV and an average particle size of 51.40 ± 21.70 nm. In ischemic stroke rat models, curcumin nanoparticle treatment significantly improved motor functions, and muscle strength and increased the activities of antioxidant enzymes like glutathione peroxidase, glutathione, glutathione S-transferase, superoxide dismutase and catalase, reducing oxidative stress and inflammation. Curcumin nanoparticles showed significant neuroprotective effects in ischemic stroke models.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221376 | PMC |
| http://dx.doi.org/10.2217/nnm-2024-0008 | DOI Listing |
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