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Differential relationships between physical activity and pain phenotypes in individuals with spinal cord injury. | LitMetric

AI Article Synopsis

  • * Using wrist-worn accelerometers, researchers tracked physical activity and daily pain ratings in 17 SCI individuals for a week, finding a significant negative correlation between moderate-to-vigorous physical activity (MVPA) and pain intensity in the neuropathic pain group, but not in the nociceptive pain group.
  • * Results suggest that pain location varies among subgroups within nociceptive pain, indicating the complexity of pain types and their responses to exercise, which could lead to

Article Abstract

Background: Chronic pain affects 70% of individuals with spinal cord injury (SCI) and leads to declines in health and quality of life. Neuropathic and nociceptive pain are phenotypes derived from different mechanisms that contribute to pain perception. The objective of this research was to investigate differential pain responses to moderate-to-vigorous physical activity (MVPA) in two chronic pain phenotypes: neuropathic and nociceptive pain.

Methods: Community-based physical activity levels were collected for one week in 17 individuals with SCI using a wrist-worn accelerometer, and daily pain ratings were assessed and categorized by phenotype. Physical activity levels were summarized to calculate minutes of MVPA. Correlational analyses were conducted to compare relationships between pain intensity and MVPA across individual participants and between pain phenotype groups.

Results: The neuropathic pain group revealed significant negative correlation between MVPA and pain intensity. In the nociceptive pain group, there was no significant correlation between MVPA and pain intensity. Further analysis revealed two subgroups of positive ( = 4) and negative ( = 3) correlations between MVPA and pain intensity. Pain location differed between the subgroups of nociceptive pain. Individuals with negative correlation experienced neck and upper back pain, whereas individuals with positive correlation experienced unilateral upper extremity pain.

Conclusion: Differential relationships exist between pain phenotypes and MVPA in individuals with SCI. Pain location differed between the subgroups of nociceptive pain, which we presume may indicate the presence of nociplastic pain in some individuals. These results may contribute to the advancement of personalized pain management by targeting non-pharmacological interventions for specific pain phenotypes. ClinicalTrials.gov identifier: NCT05236933..

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Source
http://dx.doi.org/10.1080/10790268.2024.2344315DOI Listing

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