AI Article Synopsis
- Autologous fat grafting (AFG) has inconsistent survival rates, presenting challenges for its use in plastic surgery, making improvements essential.
- The study investigated the role of the PPAR-γ agonist rosiglitazone in enhancing the survival and quality of fat grafts, showing positive effects on adipose integrity and reduced complications.
- Findings revealed that rosiglitazone promotes the infiltration of M2 macrophages, which aid in reducing inflammation and enhancing fat regeneration, suggesting potential new strategies for AFG clinical applications.
Article Abstract
The unpredictable survival rate of autologous fat grafting (AFG) seriously affects its clinical application. Improving the survival rate of AFG has become an unresolved issue in plastic surgery. Peroxisome proliferator-activated receptor-γ (PPAR-γ) regulates the adipogenic differentiation of adipocytes, but the functional mechanism in AFG remains unclear. In this study, we established an animal model of AFG and demonstrated the superior therapeutic effect of PPAR-γ regulation in the process of AFG. From day 3 after fat grafting, the PPAR-γ agonist rosiglitazone group consistently showed better adipose integrity, fewer oil cysts, and fibrosis. Massive macrophage infiltration was observed after 7 days. At the same time, M2 macrophages begin to appear. At day 14, M2 macrophages gradually became the dominant cell population, which suppressed inflammation and promoted revascularization and fat regeneration. In addition, transcriptome sequencing showed that the differentially expressed genes in the Rosiglitazone group were associated with the pathways of adipose regeneration, differentiation, and angiogenesis; these results provide new ideas for clinical treatment.
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| http://dx.doi.org/10.1096/fj.202400126R | DOI Listing |
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