[Expression of CD30 in Patients with Diffuse Large B-Cell Lymphoma and Clinical Significance].

Objective: To investigate the expression and clinical significance of CD30 in patients with diffuse large B-cell lymphoma (DLBCL).

Methods: A retrospective analysis was conducted on 124 cases of primary DLBCL diagnosed at Changzhou Second People's Hospital Affiliated with Nanjing Medical University from January 2018 to July 2020. The expression of CD30 in patients with DLBCL was detected by immunohistochemical method, and the clinicopathological characteristics were analyzed and compared between CD30 and CD30 groups. Kaplan-Meier analysis was used for survival analysis. The relationship between CD30 expression and clinical features and prognosis were analyzed.

Results: Among the 124 patients with DLBCL, 19 patients expressed CD30, and the positive rate is 15.32%. The clinico-pathological characteristics of CD30 in patients with DLBCL were characterized by low age, more common in males, fewer extranodal lesions, lower international prognostic index (IPI), GCB type being more common in Hans subtype, and achieving better therapeutic effects ( < 0.05). However, there were no significant statistical differences in B-symptoms ( =0.323), Ann Arbor staging ( =0.197), Eastern Cooperative Oncology Group (ECOG) score ( =0.479), lactate dehydrogenase (LDH) ( =0.477), and the involvement of bone marrow ( =0.222). There were significant differences in OS and PFS between the CD30 and CD30 groups (χ=5.653, =0.017; χ＝4.109， =0.043), the CD30 group had a better prognosis than that of the CD30 group. The results of subgroup analysis showed that the CD30 group in the IPI score=1-2, LDH elevated group had a better prognosis ( < 0.05). In the subgroups of Ann Arbor staging III-IV ( =0.055) and non GCB type ( =0.053), the CD30 group had a good prognosis trend, but the difference was not statistically significant. The results of univariate analysis showed that the good prognosis of DLBCL patients was closely related to CD30 expression, no B-symptoms, early Ann Arbor staging, low ECOG score, normal LDH, low IPI score, fewer extranodal involvement, and obtaining the best therapeutic effect as CR (all <0.05). COX multivariate regression analysis showed that the presence of B-symptoms and achieving the best therapeutic effect as Non-CR were independent risk factors affecting the prognosis of DLBCL patients ( < 0.05).

Conclusion: The CD30 expression in DLBCL patients indicates a good prognosis and has certain diagnostic value in evaluating the prognosis of DLBCL patients.