Background: This study aimed to evaluate the safety of enhanced recovery after surgery (ERAS) in elderly patients with gastric cancer (GC).
Aim: To evaluate the safety of ERAS in elderly patients with GC.
Methods: The PubMed, EMBASE, and Cochrane Library databases were used to search for eligible studies from inception to April 1, 2023. The mean difference (MD), odds ratio (OR) and 95% confidence interval (95%CI) were pooled for analysis. The quality of the included studies was evaluated using the Newcastle-Ottawa Scale scores. We used Stata (V.16.0) software for data analysis.
Results: This study consists of six studies involving 878 elderly patients. By analyzing the clinical outcomes, we found that the ERAS group had shorter postoperative hospital stays (MD = -0.51, = 0.00%, 95%CI = -0.72 to -0.30, = 0.00); earlier times to first flatus (defecation; MD = -0.30, I² = 0.00%, 95%CI = -0.55 to -0.06, = 0.02); less intestinal obstruction (OR = 3.24, = 0.00%, 95%CI = 1.07 to 9.78, = 0.04); less nausea and vomiting (OR = 4.07, = 0.00%, 95%CI = 1.29 to 12.84, = 0.02); and less gastric retention (OR = 5.69, = 2.46%, 95%CI = 2.00 to 16.20, = 0.00). Our results showed that the conventional group had a greater mortality rate than the ERAS group (OR = 0.24, = 0.00%, 95%CI = 0.07 to 0.84, = 0.03). However, there was no statistically significant difference in major complications between the ERAS group and the conventional group (OR = 0.67, = 0.00%, 95%CI = 0.38 to 1.18, = 0.16).
Conclusion: Compared to those with conventional recovery, elderly GC patients who received the ERAS protocol after surgery had a lower risk of mortality.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11037074 | PMC |
| http://dx.doi.org/10.4251/wjgo.v16.i4.1334 | DOI Listing |
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