The quest for extending lifespan and promoting a healthy aging has been a longstanding pursuit in the field of aging research. The control of aging and age-related diseases by nitric oxide (NO) and cGMP signaling is a broadly conserved process from worms to human. Here we show that TOP-N53, a dual-acting NO donor and PDE5 inhibitor, can increase both lifespan and health span in .
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11040393 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001090 | DOI Listing |
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