AI Article Synopsis
- Type 2 diabetes mellitus (T2DM) related to obesity is becoming more common, and while synthetic drugs exist, they can have side effects.
- Research shows that miR8175, a plant miRNA from burdock root, effectively improves glucose metabolism in diabetic mice on a high-fat diet.
- The study suggests that burdock decoction and miR8175 enhance insulin sensitivity by targeting specific pathways, highlighting the potential health benefits of plant-derived nutrients.
Article Abstract
The incidence of type 2 diabetes mellitus (T2DM) induced by obesity is rapidly increasing. Although there are many synthetic drugs for treating T2DM, they have various side effects. Here, we report that miR8175, a plant miRNA from burdock root, has effective antidiabetic activity. After administration of burdock decoction or synthetic miR8175 by gavage, both burdock decoction and miR8175 can significantly improve the impaired glucose metabolism of diabetic mice induced by a high-fat diet (HFD). Our results demonstrate that burdock decoction and miR8175 enhance the insulin sensitivity of the hepatic insulin signaling pathway by targeting and , which may be the reason for the improvement in metabolism. This study provides a theoretical basis for the main active component and molecular mechanism of burdock to improve insulin resistance. And the study also suggests that plant miRNA may be an indispensable nutrient for maintaining human health.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11039404 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.109705 | DOI Listing |
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