SARS-CoV-2 Omicron variant has evolved into sublineages. Here, we compared the neutralization susceptibility and viral fitness of EG.5.1 and XBB.1.9.1. Serum neutralization antibody titer against EG.5.1 was 1.71-fold lower than that for XBB.1.9.1. However, there was no significant difference in virus replication between EG.5.1 and XBB.1.9.1 in human nasal organoids and TMPRSS2/ACE2 over-expressing A549 cells. No significant difference was observed in competitive fitness and cytokine/chemokine response between EG.5.1 and XBB.1.9.1. Both EG.5.1 and XBB.1.9.1 replicated more robustly in the nasal organoid from a younger adult than that from an older adult. Our findings suggest that enhanced immune escape contributes to the dominance of EG.5.1 over earlier sublineages. The combination of population serum susceptibility testing and viral fitness evaluation with nasal organoids may hold promise in risk assessment of upcoming variants. Utilization of serum specimens and nasal organoid derived from older adults provides a targeted risk assessment for this vulnerable population.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11039328 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.109706 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
First report of multiresistance gene cfr in Enterococcus species casseliflavus and gallinarum of swine origin.
Vet Microbiol
June 2014
Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, College of Veterinary Medicine, China Agricultural University, Beijing, PR China. Electronic address:
The aim of this study was to investigate the presence and genetic environment of the multiresistance gene cfr in Enterococcus species of swine origin. Twenty-five cfr-carrying Enterococcus isolates were collected from swine in Beijing, Guangzhou, and Shandong, China. The isolates consist of 24 Enterococcus casseliflavus and one Enterococcus gallinarum isolate, and exhibited six SmaI PFGE patterns.
View Article and Find Full Text PDFVisual prey capture in larval zebrafish is controlled by identified reticulospinal neurons downstream of the tectum.
J Neurosci
October 2005
Department of Psychology, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Many vertebrates are efficient hunters and recognize their prey by innate neural mechanisms. During prey capture, the internal representation of the prey's location must be constantly updated and made available to premotor neurons that convey the information to spinal motor circuits. We studied the neural substrate of this specialized visuomotor system using high-speed video recordings of larval zebrafish and laser ablations of candidate brain structures.
View Article and Find Full Text PDFCellulase complex of the fungus Chrysosporium lucknowense: isolation and characterization of endoglucanases and cellobiohydrolases.
Biochemistry (Mosc)
May 2004
Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119899, Russia.
Using different chromatographic techniques, eight cellulolytic enzymes were isolated from the culture broth of a mutant strain of Chrysosporium lucknowense: six endoglucanases (EG: 25 kD, pI 4.0; 28 kD, pI 5.7; 44 kD, pI 6.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!