AI Article Synopsis
- In advanced Parkinson's disease, motor complications like wearing-off and dyskinesia fluctuate daily, requiring accurate monitoring for better patient care.
- A study utilized wearable devices to gather data on pulse rates and activity levels from 12 Parkinson's patients over 30 days to investigate biomarkers related to these motor complications.
- Results indicated that while individual trends varied, a higher pulse rate and activity index were observed during certain states, suggesting that these measurements could serve as effective indicators for managing symptoms, with the need for further research to confirm findings.
Article Abstract
Introduction: In the advanced stages of Parkinson's disease (PD), motor complications such as wearing-off and dyskinesia are problematic and vary daily. These symptoms need to be monitored precisely to provide adequate care for patients with advanced PD.
Methods: This study used wearable devices to explore biomarkers for motor complications by measuring multiple biomarkers in patients with PD residing in facilities and combining them with lifestyle and clinical assessments. Data on the pulse rate and activity index (metabolic equivalents) were collected from 12 patients over 30 days.
Results: The pulse rate and activity index during the and periods and were analyzed for two participants; the pulse rate and activity index did not show any particular trend in each participant; however, the pulse rate/activity index was significantly greater in the -state compared to that in the and -states, and this index in the state was significantly greater than that in the -state in both participants.
Conclusion: These results suggest the pulse rate and activity index combination would be a useful indicator of wearing-off and dyskinesia and that biometric information from wearable devices may function as a digital diary. Accumulating more cases and collecting additional data are necessary to verify our findings.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11041395 | PMC |
| http://dx.doi.org/10.3389/fneur.2024.1356042 | DOI Listing |
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