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Diagnostic enigma of pulmonary hypertension: Tale from a series of three patients.
Med J Armed Forces India
December 2024
Consultant (Radiodiagnosis), Medica Super Specialty Hospital, Kolkata, India.
Pulmonary hypertension (PH) is a complex condition with multiple etiological factors. The ability to identify a potential underlying cause is crucial for accurate diagnosis, patient management, and prognostication. This article presents a series of three patient cases to illustrate the enigmatic nature of PH diagnosis.
View Article and Find Full Text PDFThe enigmatic role of SIRT2 in the cardiovascular system: Deciphering its protective and detrimental actions to unlock new avenues for therapeutic intervention.
Curr Probl Cardiol
February 2025
Queen Elizabeth Hospital Birmingham (QEHB), Nuffield House, 3rd Floor Room 17/E, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, Dudley Road, Birmingham, West Midlands, B18 7QH.
Cardiovascular diseases (CVDs) are leading causes of mortality throughout the world, and hence, there is a critical need to elucidate their molecular mechanisms. The Sirtuin (SIRT) family of NAD+-dependent enzymes has recently been shown to play a critical role in cardiovascular health and disease, and several SIRT isoforms, especially SIRT1 and SIRT3, have been amply investigated. However, the precise function of SIRT2 is only partially explored.
View Article and Find Full Text PDFRBM15 promotes lipogenesis and malignancy in gastric cancer by regulating N6-Methyladenosine modification of ACLY mRNA in an IGF2BP2-dependent manner.
Biochim Biophys Acta Mol Cell Biol Lipids
November 2024
Department of Gastrointestinal Surgery, The Lihuili Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315000, China. Electronic address:
N6-methyladenosine (mA) and lipid metabolism reprogramming play pivotal roles in cancer development. Nevertheless, the precise functions of mA methyltransferase RNA Binding Motif Protein 15 (RBM15) and its interactions with ATP Citrate Lyase (ACLY) in gastric cancer (GC) have not been fully elucidated. In this study, we comprehensively investigate the biological roles and potential mechanisms of RBM15 and ACLY in GC.
View Article and Find Full Text PDFA decade of dinoflagellate genomics illuminating an enigmatic eukaryote cell.
BMC Genomics
October 2024
Department of Marine Sciences, University of Connecticut, Groton, CT, 06340, USA.
Dinoflagellates are a remarkable group of protists, not only for their association with harmful algal blooms and coral reefs but also for their numerous characteristics deviating from the rules of eukaryotic biology. Genome research on dinoflagellates has lagged due to their immense genome sizes in most species (~ 1-250 Gbp). Nevertheless, the last decade marked a fruitful era of dinoflagellate genomics, with 27 genomes sequenced and many insights attained.
View Article and Find Full Text PDFExplanation of puzzling FQHE at the filling fraction 3/4 in a band-hole 2D system in GaAs.
J Phys Condens Matter
September 2024
Wrocław University of Science and Technology, Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland.
A recent experiment revealed an unexpected FQHE at filling fraction 3/4 in a GaAs 2D hole system, which contradicts the composite fermion model prediction and the observation of a compressible Hall metal-type state in a twin 2D electron system in GaAs at the same filling fraction 3/4 at almost same other conditions. This finding challenges conventional effective single-quasiparticle model for FQHE exposing its limitations. We explain this experimental observation within a multiparticle approach based on a topological cyclotron commensurability criterion.
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