AI Article Synopsis

  • - Recent research links deep vein thrombosis (VTE) with inflammation and highlights the role of m6A, an important regulator in the immune system, in understanding VTE’s pathophysiology.
  • - A study analyzing blood samples from 177 VTE patients and 88 healthy individuals identified several m6A regulatory elements and used machine learning to build a diagnostic model for VTE.
  • - Findings revealed significant differences in m6A modification patterns related to immune cell activity and autophagy, uncovering two key autophagy genes and the m6A regulator YTHDF3, suggesting new insights into the mechanisms underlying VTE and potential therapeutic approaches.

Article Abstract

Recent studies have found a link between deep vein thrombosis and inflammatory reactions. N6-methyladenosine (m6A), a crucial element in immunological regulation, is believed to contribute to the pathophysiology of venous thromboembolism (VTE). However, how the m6A-modified immune microenvironment is involved in VTE remains unclear. In the present study, we identified a relationship between VTE and the expression of several m6A regulatory elements by analyzing peripheral blood samples from 177 patients with VTE and 88 healthy controls from public GEO databases GSE19151 and GSE48000. We used machine learning to identify essential genes and constructed a diagnostic model for VTE using multivariate logistic regression. Unsupervised cluster analysis revealed a marked difference between m6A modification patterns in terms of immune cell infiltration, inflammatory reactivity, and autophagy. We identified two m6A-related autophagy genes (i.e., CHMP2B and SIRT1) and the crucial m6A regulator YTHDF3 using bioinformatics. We also examined two potential mechanisms through which YTHDF3 may affect VTE. m6A modification, immunity, and autophagy are closely linked in VTE, offering novel mechanistic and therapeutic insights.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11044431PMC
http://dx.doi.org/10.1186/s12864-024-10294-2DOI Listing

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