AI Article Synopsis
- Recent research indicates that mitochondria in white adipocytes may have distinct functions similar to those found in brown adipocytes, involving different mitochondrial fractions.
- Two types of mitochondria were identified in white adipocytes: cytoplasmic mitochondria (CMw) and peridroplet mitochondria (PDMw).
- CMw showed higher β-oxidation activity, suggesting its role in fat breakdown, while PDMw is linked to fat storage processes.
Article Abstract
The role of mitochondria in white adipocytes (WAs) has not been fully explored. A recent study revealed that brown adipocytes contain functionally distinct mitochondrial fractions, cytoplasmic mitochondria, and peridroplet mitochondria. However, it is not known whether such a functional division of mitochondria exists in WA. Herein, we observed that mitochondria could be imaged and mitochondrial DNA and protein detected in pellets obtained from the cytoplasmic layer and oil layer of WAs after centrifugation. The mitochondria in each fraction were designated as cytoplasmic mitochondria (CMw) and peridroplet mitochondria (PDMw) in WAs, respectively. CMw had higher β-oxidation activity than PDMw, and PDMw was associated with diacylglycerol acyltransferase 2. Therefore, CMw may be involved in β-oxidation and PDMw in droplet expansion in WAs.
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| http://dx.doi.org/10.1002/1873-3468.14877 | DOI Listing |
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