Introduction: reconstruction of large bone defects using modular knee arthroplasty (MKA) presents a significant challenge in terms of functionality. The objective of the present work was to identify the different prognostic factors associated with failure of MKA in cancer patients.
Material And Methods: a retrospective cohort study was conducted, including patients with a diagnosis of musculoskeletal tumor in the distal femur or proximal tibia, who underwent MKA between January 1, 2010, and December 31, 2021.
Results: 49 patients were included, of which 25 (51.02%) were women and 24 (48.98%) men, with a mean age of 29.57 years. Of these, 14 (28.57%) patients experienced some type of MKA failure. The most frequent complication that led to failure was periprosthetic infection, observed in seven (14.29%) patients. Variables associated with MKA failure included biopsies performed outside our hospital (HR 3.2, 95% CI 1.4-6.4, p = 0.02), the length of the long axis of the tumor (HR 2.1, 95% CI 1.2-4.6, p = 0.01) and a prolonged surgical time (HR 3.37, 95% CI 1.1-8.6, p = 0.04).
Conclusion: the most significant prognostic factors associated with MKA failure in our cohort were tumor size, prolonged surgical time, and performance of the diagnostic biopsy in a center not specialized in the management of this type of patient. These findings highlight the importance of considering these variables to improve outcomes in patients undergoing MKA.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
-polarized M2-like tumor-associated macrophages accelerate colorectal cancer development via IL-8 secretion.
Anim Cells Syst (Seoul)
December 2024
Department of Oral Biochemistry, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea.
(), a periodontal pathogen, has been implicated in the impairment of anti-tumor responses in colorectal cancer (CRC). The tumor microenvironment in CRC involves tumor-associated macrophages (TAMs), which are pivotal in modulating tumor-associated immune responses. The polarization of TAMs towards an M2-like phenotype promotes CRC progression by suppressing the immune system.
View Article and Find Full Text PDFSociodemographic factors associated with trajectories of depression among urban refugee youth in Kampala, Uganda: A longitudinal cohort study.
Glob Ment Health (Camb)
December 2024
Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Background: There is a high prevalence of depression among refugee youth in low- and middle-income countries, yet depression trajectories are understudied. This study examined depression trajectories, and factors associated with trajectories, among urban refugee youth in Kampala, Uganda.
Methods: We conducted a longitudinal cohort study with refugee youth aged 16-24 in Kampala, Uganda.
Characterization of children's prospective prescription review and exploration of factors influencing the success of interventions.
Ther Adv Drug Saf
January 2025
Department of Pharmacy, Children's Hospital of Chongqing Medical University, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing, 400014, China.
Background: Medication safety is crucial in clinical care. Although many hospitals have implemented prospective prescription review systems to manage medication use, the impact of these systems on pediatric patients is not yet fully understood.
Objectives: We explore the characteristics and economic impacts of pediatric prospective prescription review and identify factors influencing intervention success rates.
The influence of proactive personality on students' knowledge sharing: the chain mediating effect of class climate and learning engagement.
Front Psychol
December 2024
School of Philosophy and Sociology, Jilin University, Changchun, China.
Introduction: Knowledge sharing is an effective means of knowledge management in colleges and universities, which is of great significance for improving the quality and efficiency of universities and enhancing the balanced development of educational resources. The present study investigated the influence students' proactive personalities drive knowledge-sharing activities, and examined the significance of class climate and learning engagement as mediating factors, utilizing the perspectives of social exchange theory (SET) and the job demands and resources model (JD-R) .
Methods: A convenience sampling method was employed to survey 1,053 Chinese college students, and evaluated them using the Proactive Personality Scale (PPS), Learning Engagement Scale (LES), Class Climate Scale (CCS), and Knowledge Sharing Behavior Scale (KSBS).
The attraction of evil. An investigation of factors explaining women's romantic parasocial relationships with bad guys in movies and series.
Front Psychol
December 2024
Department of Media and Business Communication, Institute Human-Computer-Media, University of Würzburg, Würzburg, Germany.
The attractiveness of bad boys can be seen as a cultural phenomenon that can be found in different areas of society and art. In the media, too, the bad boy fulfills social expectations in terms of masculinity and is often portrayed as dominant, violent, hard, unemotional and aggressive. Women may feel attracted to this male dominance under certain conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!