AI Article Synopsis
- Rotator cuff injuries happen a lot in the U.S., leading to over 500,000 surgeries each year, but many do not work as well as hoped.
- A special tissue called the subacromial bursa, which sits near the rotator cuff, seems to help with injury healing and might need to be kept during surgeries.
- Research in rats showed that the bursa helps protect nearby tendons and promotes healing, and it might also be useful for delivering medicine to reduce pain and inflammation in damaged tendons.
Article Abstract
Rotator cuff injuries result in more than 500,000 surgeries annually in the United States, many of which fail. These surgeries typically involve repair of the injured tendon and removal of the subacromial bursa, a synovial-like tissue that sits between the rotator cuff and the acromion. The subacromial bursa has been implicated in rotator cuff pathogenesis and healing. Using proteomic profiling of bursa samples from nine patients with rotator cuff injury, we show that the bursa responds to injury in the underlying tendon. In a rat model of supraspinatus tenotomy, we evaluated the bursa's effect on the injured supraspinatus tendon, the uninjured infraspinatus tendon, and the underlying humeral head. The bursa protected the intact infraspinatus tendon adjacent to the injured supraspinatus tendon by maintaining its mechanical properties and protected the underlying humeral head by maintaining bone morphometry. The bursa promoted an inflammatory response in injured rat tendon, initiating expression of genes associated with wound healing, including and . These results were confirmed in rat bursa organ cultures. To evaluate the potential of the bursa as a therapeutic target, polymer microspheres loaded with dexamethasone were delivered to the intact bursae of rats after tenotomy. Dexamethasone released from the bursa reduced expression in injured rat supraspinatus tendon, suggesting that the bursa could be used for drug delivery to reduce inflammation in the healing tendon. Our findings indicate that the subacromial bursa contributes to healing in underlying tissues of the shoulder joint, suggesting that its removal during rotator cuff surgery should be reconsidered.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646107 | PMC |
| http://dx.doi.org/10.1126/scitranslmed.add8273 | DOI Listing |
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