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Clinical studies in Myxomatous Mitral Valve Disease dogs: most prescribed ACEI inhibits ACE2 enzyme activity and ARB increases AngII pool in plasma.
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Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
The hypertension patient population has doubled since 1990, affecting 1.3 billion globally and >75% live in low-and middle-income countries. Angiotensin Converting Enzyme Inhibitors (ACEI) and Angiotensin Receptor Blockers (ARB) are the most prescribed drugs (>160 million times in the US), but mortality increased >30% since 1990s globally.
View Article and Find Full Text PDFUltrafiltration membrane modelling: Comparing two mathematical models by sensitivity and uncertainty analysis for Palermo and Corleone (Italy) water reuse case studies.
Sci Total Environ
January 2025
Center for Water Research, Advanced Institute of Natural Sciences, Beijing Normal University, 519087 Zhuhai, China.
The new EU Urban Wastewater Treatment Directive requires stricter limits introducing quaternary treatments and poses significant challenges to achieving a sustainable environment. Advanced membrane-based treatment processes combined with mathematical models can be a good solution for facing the challenges above. Most existing literature on membrane filtration models primarily focuses on membrane bioreactors, lacking mechanistic models on ultrafiltration (UF) membranes.
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PLoS One
January 2025
C.E. Lynn College of Nursing, Florida Atlantic University, Boca Raton, FL, United States of America.
Background: Ambient air pollution, detrimental built and social environments, social isolation (SI), low socioeconomic status (SES), and rural (versus urban) residence have been associated with cognitive decline and risk of Alzheimer's disease and related dementias (ADRD). Research is needed to investigate the influence of ambient air pollution and built and social environments on SI and cognitive decline among rural, disadvantaged, ethnic minority communities. To address this gap, this cohort study will recruit an ethnoracially diverse, rural Florida sample in geographic proximity to seasonal agricultural burning.
View Article and Find Full Text PDFA qualitative exploration of stakeholder perspectives of independent prescribing by newly qualified pharmacists: a theoretical domains interview study.
Int J Pharm Pract
January 2025
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Objectives: To explore the perspectives of stakeholders on the General Pharmaceutical Council's revised Standards for the Initial Education and Training of Pharmacists that enable pharmacists to prescribe at the point of registration, from 2026.
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Br J Gen Pract
January 2025
The University of Edinburgh, The Usher Institute, Edinburgh, United Kingdom
Background: The 2018 Scottish GP contract established GP Clusters and multidisciplinary team (MDT) expansion. Qualitative studies have suggested sub-optimal progress.
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