Purpose: Smile design software increasingly relies on artificial intelligence (AI). However, using AI for smile design raises numerous technical and ethical concerns. This study aimed to evaluate these ethical issues.
Methods: An international consortium of experts specialized in AI, dentistry, and smile design was engaged to emulate and assess the ethical challenges raised by the use of AI for smile design. An e-Delphi protocol was used to seek the agreement of the ITU-WHO group on well-established ethical principles regarding the use of AI (wellness, respect for autonomy, privacy protection, solidarity, governance, equity, diversity, expertise/prudence, accountability/responsibility, sustainability, and transparency). Each principle included examples of ethical challenges that users might encounter when using AI for smile design.
Results: On the first round of the e-Delphi exercise, participants agreed that seven items should be considered in smile design (diversity, transparency, wellness, privacy protection, prudence, law and governance, and sustainable development), but the remaining four items (equity, accountability and responsibility, solidarity, and respect of autonomy) were rejected and had to be reformulated. After a second round, participants agreed to all items that should be considered while using AI for smile design.
Conclusions: AI development and deployment for smile design should abide by the ethical principles of wellness, respect for autonomy, privacy protection, solidarity, governance, equity, diversity, expertise/prudence, accountability/responsibility, sustainability, and transparency.
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http://dx.doi.org/10.1111/jopr.13858 | DOI Listing |
Cleft Palate Craniofac J
January 2025
Global Smile Foundation, Norwood, MA, USA.
Objective: This study aims to assess the safety and efficacy of solely using local anesthetics for cleft lip repair and/or revision in adolescent and adult patients.
Design: Systematic review.
Setting: Clinical studies describing the use of local anesthetics in cleft lip repair procedures.
Nutrients
December 2024
Unit of Pediatric Clinic, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Background: Vitamin D plays a pivotal role in early childhood development, influencing skeletal strength, neuromuscular coordination, and neurodevelopment. This study aimed to evaluate the impact of different durations of Vitamin D supplementation on achieving developmental milestones.
Methods: A retrospective study was conducted on 209 children, divided into two cohorts based on Vitamin D supplementation duration: six months ( = 102) and twelve months ( = 107).
Peptide therapeutics, a major class of medicines, have achieved remarkable success across diseases such as diabetes and cancer, with landmark examples such as GLP-1 receptor agonists revolutionizing the treatment of type-2 diabetes and obesity. Despite their success, designing peptides that satisfy multiple conflicting objectives, such as target binding affinity, solubility, and membrane permeability, remains a major challenge. Classical drug development and structure-based design are ineffective for such tasks, as they fail to optimize global functional properties critical for therapeutic efficacy.
View Article and Find Full Text PDFOrg Biomol Chem
January 2025
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
Succinyldiamide derivatives are important structural motifs in various natural products, pharmaceuticals, and functional materials. Herein, a novel, mild, and environmentally friendly method was developed for synthesizing functionalized succinyldiamides each containing a quaternary carbon center. This strategy was designed to involve photocatalytic decarboxylation of readily available oxalic monoamide using a non-precious metal photocatalyst, 4CzIPN, followed by a free-radical addition/Smiles rearrangement cascade reaction of -aryl--(arylsulfonyl)acrylamides.
View Article and Find Full Text PDFJ Dent Child (Chic)
September 2024
School of Dentistry, Ceuma University, Imperatriz, Maranhão, Brazil.
The quest for an esthetically pleasing smile is a key driver in seeking dental interventions aimed at achieving a more balanced and harmonious appearance. The purpose of this report is to discuss the restoration of conical lateral incisors in an 11-year-old patient. The treatment approach employed direct composite resin restorations associated with the Digital Smile Design (DSD) technology.
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