Clinical and Demographic Factors Associated With Kaposi Sarcoma-Associated Herpesvirus Shedding in Saliva or Cervical Secretions in a Cohort of Tanzanian Women.

Background: Reasons for the high prevalence of Kaposi sarcoma-associated herpesvirus (KSHV) in sub-Saharan Africa, and risk factors leading to viral reactivation and shedding, remain largely undefined. Preliminary studies have suggested that schistosome infection, which has been associated with impaired viral control, is associated with KSHV. In this study we sought to determine the relationship between active or infection and KSHV shedding.

Methods: We quantified KSHV DNA in saliva and cervical swabs from 2 cohorts of women living in northwestern Tanzanian communities endemic for or by real-time polymerase chain reaction. χ and Fisher exact tests were used to determine differences in clinical and demographic factors between those who were and were not shedding KSHV.

Results: Among 139 total women, 44.6% were KSHV seropositive. Six percent of those with and 17.1% of those with were actively shedding KSHV in saliva and none in cervical samples. Women from the cohort who were shedding virus reported infertility more frequently (80% vs 19.5%, = .009). There was no difference in frequency of KSHV salivary shedding between schistosome-infected and -uninfected women.

Conclusions: In an area with high KSHV seroprevalence and endemic schistosome infections, we provide the first report with data demonstrating no association between schistosome infection and salivary or cervical herpesvirus shedding. KSHV salivary shedding was associated with infertility, a known effect of another herpesvirus, human herpesvirus 6.