Polymeric Microneedles for Health Care Monitoring: An Emerging Trend.

ACS Sens

INL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330 Braga, Portugal.

Published: May 2024

Bioanalyte collection by blood draw is a painful process, prone to needle phobia and injuries. Microneedles can be engineered to penetrate the epidermal skin barrier and collect analytes from the interstitial fluid, arising as a safe, painless, and effective alternative to hypodermic needles. Although there are plenty of reviews on the various types of microneedles and their use as drug delivery systems, there is a lack of systematization on the application of polymeric microneedles for diagnosis. In this review, we focus on the current state of the art of this field, while providing information on safety, preclinical and clinical trials, and market distribution, to outline what we believe will be the future of health monitoring.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129353PMC
http://dx.doi.org/10.1021/acssensors.4c00612DOI Listing

Publication Analysis

Top Keywords

polymeric microneedles
8
microneedles health
4
health care
4
care monitoring
4
monitoring emerging
4
emerging trend
4
trend bioanalyte
4
bioanalyte collection
4
collection blood
4
blood draw
4

Similar Publications

Microneedle-delivered adeno-associated virus vaccine amplified anti-viral immunity by improving antigen-presenting cells infection.

J Control Release

January 2025

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address:

Adeno-associated viruses (AAV) have significant potential as vaccine carriers due to their excellent biosafety and efficient antigen gene delivery. However, most AAV vaccines show limited capacity to transduce antigen-presenting cells (APCs) following intramuscular injection which may cause inadequate cellular immune responses and undesired side effects due to transducing other tissues or cells. Herein, we developed a soluble microneedle patch for targeting the AAV vaccines to the epidermal and dermal APCs.

View Article and Find Full Text PDF

Progression of photoresin-based microneedles: From established drug delivery to emerging biosensing technologies.

Biosens Bioelectron

January 2025

Department of Electrical Engineering (ESAT-MNS), Catholic University of Leuven (KU Leuven), 3001, Leuven, Belgium; KU Leuven, Department of Physics and Astronomy (HF), Celestij€nenlaan 300D, 3001, Leuven, Belgium; Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnology, Arnesano, Italy.

Microneedles have emerged as a highly promising technology for advancing chemical biosensing and drug delivery applications, offering a minimally invasive, efficient, and versatile approach to healthcare innovation. This review provides a comprehensive analysis of photoresin-based microneedles, with a particular focus on SU-8 photoresin due to its favorable mechanical properties, biocompatibility, and ease of fabrication. Advanced techniques for surface modification are discussed to enhance the functionality of microneedles, enabling their application in precise biochemical diagnostics and effective drug therapy.

View Article and Find Full Text PDF

The combination of the active compounds curcumin and piperine (CP) is effective as an antimalarial; however, the solubility and bioavailability of CP are very low. This study aims to formulate CP in nanoparticles (NP), which are then fabricated into dissolving microneedles (DMN). The NPs were prepared with a concentration ratio of CP-Chitosan-So.

View Article and Find Full Text PDF

Smart core-shell microneedles for psoriasis therapy: In situ self-assembly of calcium ion-coordinated dexamethasone hydrogel.

J Control Release

January 2025

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511443, China. Electronic address:

Psoriasis is a prevalent relapsing dermatological condition that often necessitates lifelong treatment. The distinctive thickening of the stratum corneum presents a challenge to drug penetration. The employment of microneedles has been demonstrated to enhance the transdermal drug delivery efficacy by creating multiple microchannels in the skin.

View Article and Find Full Text PDF

Polydopamine-Mediated, Centrifugal Force-Driven Gold Nanoparticle-Deposited Microneedle SERS Sensors for Food Safety Monitoring Theoretical Study of the SERS Substrate Fabrication.

ACS Sens

January 2025

The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, P. R. China.

Microneedle (MN) sensors have great promise for food safety detection, but the rapid preparation of MNs for surface-enhanced Raman scattering (SERS) sensors with tunable and homogeneous nanoparticles remains a great challenge. To address this, a SERS sensor of gold nanoparticles@polydopamine@poly(methyl methacrylate) MN (AuNPs@PDA@PMMA-MN) was developed. The extended-Derjaguin-Landau-Verwey-Overbeek theory was applied to calculate the interaction energy between AuNPs and PDA.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!