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| http://dx.doi.org/10.1192/j.eurpsy.2024.1746 | DOI Listing |
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Minimal clinically important difference in obsessive-compulsive disorder.
World Psychiatry
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Department of Clinical Sciences, Lund University, Lund, Sweden.
Early life microbial succession in the gut follows common patterns in humans across the globe.
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Department of Biological Sciences, Wellesley College, Wellesley, MA, USA.
Characterizing the dynamics of microbial community succession in the infant gut microbiome is crucial for understanding child health and development, but no normative model currently exists. Here, we estimate child age using gut microbial taxonomic relative abundances from metagenomes, with high temporal resolution (±3 months) for the first 1.5 years of life.
View Article and Find Full Text PDFmHealth-Augmented Care for Reducing Depression Symptom Severity Among Patients With Chronic Pain: Exploratory, Retrospective Cohort Study.
JMIR Mhealth Uhealth
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Clinical Operations, NeuroFlow, Inc, 1601 Market St, Suite 1500, Philadelphia, PA, 19103, United States, 1 3026893520.
Background: Depression and chronic pain are commonly comorbid, mutually reinforcing, and debilitating. Emerging approaches to mobile behavioral health care (mHealth) promise to improve outcomes for patients with comorbid depression and chronic pain by integrating with existing care models to bolster support and continuity between clinical visits; however, the evidence base supporting the use of mHealth to augment care for this patient population is limited.
Objective: To develop an evidence base that sets the stage for future research, we aimed to explore the associations between changes in depression severity and various integrated care models, with and without mHealth augmentation, among patients with comorbid depression and nonmalignant chronic pain.
Default mode network functional connectivity as a transdiagnostic biomarker of cognitive function.
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Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Brain and Cognitive Science at the McGovern Institute for Brain Research at Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Psychology, Northeastern University. Electronic address:
The default mode network (DMN) is intricately linked with processes such as self-referential thinking, episodic memory recall, goal-directed cognition, self-projection, and theory of mind. Over recent years, there has been a surge in examining its functional connectivity, particularly its relationship with frontoparietal networks (FPN) involved in top-down attention, executive function, and cognitive control. The fluidity in switching between these internal and external modes of processing-highlighted by anti-correlated functional connectivity-has been proposed as an indicator of cognitive health.
View Article and Find Full Text PDFTask relevant autoencoding enhances machine learning for human neuroscience.
Sci Rep
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Department of Cognitive Sciences, University of California, 2201 Social & Behavioral Sciences Gateway, Irvine, CA, 92697, USA.
In human neuroscience, machine learning can help reveal lower-dimensional neural representations relevant to subjects' behavior. However, state-of-the-art models typically require large datasets to train, and so are prone to overfitting on human neuroimaging data that often possess few samples but many input dimensions. Here, we capitalized on the fact that the features we seek in human neuroscience are precisely those relevant to subjects' behavior rather than noise or other irrelevant factors.
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