AI Article Synopsis
- - Glioma is a challenging disease to treat, with poor outcomes and the necessity for new therapies, as current treatments face difficulties in drug delivery across the blood-brain barrier and within tumors.
- - Mesenchymal stem cells (MSCs) are being investigated as promising vehicles for glioma therapies because they can cross the blood-brain barrier, target tumor cells effectively, and evade the immune system.
- - Research is ongoing to enhance the effectiveness of MSCs in delivering chemotherapy, gene therapy, and oncolytic viral therapies, with the hope that improving their migration to gliomas will boost treatment success for patients.
Article Abstract
Glioma is a disease with a poor prognosis despite the availability of multimodality treatments, and the development of novel therapies is urgently needed. Challenges in glioma treatment include the difficulty for drugs to cross the blood-brain barrier when administered systemically and poor drug diffusion when administered locally. Mesenchymal stem cells exhibit advantages for glioma therapy because of their ability to pass through the blood-brain barrier and migrate to tumor cells and their tolerance to the immune system. Therefore, mesenchymal stem cells have been explored as vehicles for various therapeutic agents for glioma treatment. Mesenchymal stem cells loaded with chemotherapeutic drugs show improved penetration and tumor accumulation. For gene therapy, mesenchymal stem cells can be used as vehicles for suicide genes, the so-called gene-directed enzyme prodrug therapy. Mesenchymal stem cell-based oncolytic viral therapies have been attempted in recent years to enhance the efficacy of infection against the tumor, viral replication, and distribution of viral particles. Many uncertainties remain regarding the function and behavior of mesenchymal stem cells in gliomas. However, strategies to increase mesenchymal stem cell migration to gliomas may improve the delivery of therapeutic agents and enhance their anti-tumor effects, representing promising potential for patient treatment.
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| http://dx.doi.org/10.1038/s41417-024-00775-7 | DOI Listing |
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