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Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases. | LitMetric

Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases.

Adv Drug Deliv Rev

Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Published: June 2024

AI Article Synopsis

  • * Focused ultrasound (FUS) combined with contrast agents like microbubbles (MBs) shows promise as a noninvasive method to temporarily open the BBB, allowing better drug delivery for these diseases.
  • * This review details how FUS/MBs work, highlights recent advancements in this approach for treating neurodegenerative diseases, and discusses ongoing challenges and future directions.

Article Abstract

With the aging population on the rise, neurodegenerative disorders have taken center stage as a significant health concern. The blood-brain barrier (BBB) plays an important role to maintain the stability of central nervous system, yet it poses a formidable obstacle to delivering drugs for neurodegenerative disease therapy. Various methods have been devised to confront this challenge, each carrying its own set of limitations. One particularly promising noninvasive approach involves the utilization of focused ultrasound (FUS) combined with contrast agents-microbubbles (MBs) to achieve transient and reversible BBB opening. This review provides a comprehensive exploration of the fundamental mechanisms behind FUS/MBs-mediated BBB opening and spotlights recent breakthroughs in its application for neurodegenerative diseases. Furthermore, it addresses the current challenges and presents future perspectives in this field.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.addr.2024.115323DOI Listing

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