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Heritability, phenotypic, and genetic correlations across dimensional and categorical models of bipolar disorder in a family sample.
J Affect Disord
March 2025
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Electronic address:
Background: Bipolar disorder (BD) presents with a wide range of symptoms that vary among relatives, casting doubt on categorical illness models. To address this uncertainty, we investigated the heritability and genetic relationships between categorical and dimensional models of BD in a family sample.
Methods: This retrospective study included participants (n = 397 Females, n = 329 Males, mean age 47 yr) in the Amish-Mennonite Bipolar Genetics (AMBiGen) study from North and South America that were assigned categorical mood disorder diagnoses ("narrow" or "broad") by structured psychiatric interview and completed the Mood Disorder Questionnaire (MDQ), which assesses lifetime history of manic symptoms and associated impairment.
Accelerating Heritability, Genetic Correlation, and Genome-Wide Association Imaging Genetic Analyses in Complex Pedigrees.
Hum Brain Mapp
December 2024
Department of Psychiatry and Behavioral Sciences, University of Texas, Health Science Center Houston, Houston, Texas, USA.
National and international biobanking efforts led to the collection of large and inclusive imaging genetics datasets that enable examination of the contribution of genetic and environmental factors to human brains in illness and health. High-resolution neuroimaging (~10 voxels) and genetic (10 single nucleotide polymorphic [SNP] variants) data are available in statistically powerful (N = 10) epidemiological and disorder-focused samples. Performing imaging genetics analyses at full resolution afforded in these datasets is a formidable computational task even under the assumption of unrelatedness among the subjects.
View Article and Find Full Text PDFOn 8 April 2024, a rare total solar eclipse (TSE) passed over western New York State (NYS), the first since 1925 and the last one until 2079. The NYS Mesonet (NYSM) consisting of 126 weather stations with 55 on the totality path provides unprecedented surface, profile, and flux data and camera images during the TSE. Here we use NYSM observations to characterize the TSE's impacts at the surface, in the planetary boundary layer (PBL), and on surface fluxes and CO concentrations.
View Article and Find Full Text PDFSolar retinopathy following the April 2024 eclipse in Quebec, Canada.
Can J Ophthalmol
November 2024
Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada; Université de Montréal, Montreal, QC, Canada.
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