Background: Human T cells play an important role in immunity against tuberculosis (TB) infection. Activating receptor HLA-DR and inhibitory receptor KLRG1 are critical regulators of T cell function during viral infection and tumorigenesis, but they have been less studied in TB infection.
Methods: In this study, we explored the relationship between CD3 T cell expression of HLA-DR and KLRG1 receptors and function against TB infection. Flow cytometry was conducted to assess the immunomodulatory effects of HLA-DR and KLRG1 receptors on CD3 T cells in patients with different TB infection status.
Results: We found activating receptors HLA-DR, NKG2C, CD57 and NKP46, and inhibitory receptors KLRG1 and KIR on CD3 T cells in different TB infection status showed different distribution patterns; the cytotoxic potential and cytokine secretion capacity of CD3 T cells after Mtb-specific antigen stimulation were significantly enhanced in TB infection groups. Further studies revealed HLA-DR T and KLRG1 T cells expressed higher activating and inhibitory receptors than the negative population. In addition, the expression of cytotoxic potential and cytokine secretion capacity of HLA-DR T and KLRG1 T cells was significantly higher than that of HLA-DR T and KLRG1 T cells.
Conclusions: Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3 T cells in TB patients, suggesting CD3 T cells expressing HLA-DR and KLRG1 are important effector cell phenotypes involved in the host anti-TB infection. HLA-DR and KLRG1 expressed by CD3 T cells may be potential predictive markers of TB disease progression and clinical immune assessment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.intimp.2024.112115 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3 T cells in tuberculosis patients.
Int Immunopharmacol
May 2024
Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China. Electronic address:
Background: Human T cells play an important role in immunity against tuberculosis (TB) infection. Activating receptor HLA-DR and inhibitory receptor KLRG1 are critical regulators of T cell function during viral infection and tumorigenesis, but they have been less studied in TB infection.
Methods: In this study, we explored the relationship between CD3 T cell expression of HLA-DR and KLRG1 receptors and function against TB infection.
PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis.
Arthritis Res Ther
January 2024
Columbia Center for Translational Immunology, Columbia University Medical Center, 650 W 168 St. BB-1701F, New York, NY, 10032, USA.
Background: PD-1 is an immune checkpoint on T cells, and interventions to block this receptor result in T cell activation and enhanced immune response to tumors and pathogens. Reciprocally, despite a decade of research, approaches to treat autoimmunity with PD-1 agonists have only had limited successful. To resolve this, new methods must be developed to augment PD-1 function beyond engaging the receptor.
View Article and Find Full Text PDFSingle-cell transcriptomics of peripheral blood mononuclear cells indicates impaired immune and inflammatory responses in alcohol-associated hepatitis.
Hum Immunol
January 2024
Department of Epidemiology and Biostatistics, University of California, Irvine, CA, USA. Electronic address:
Alcohol-associated hepatitis (AH) is often diagnosed at advanced stages, and severe AH usually carries poor prognosis and high short-term mortality. In addition, it is challenging to understand the molecular mechanisms of immune dysregulation and inflammation in AH due to the cellular complexity and heterogeneity. Using single-cell RNA sequencing, previous studies found that AH causes dysfunctional innate immune response in monocytes, involving activation of pattern recognition receptors (PRRs) and cytokine signaling pathways.
View Article and Find Full Text PDFBackground: PD-1 is an immune checkpoint on T cells and interventions to block this receptor result in T cell activation and enhanced immune response to tumors. Paired to that, and despite a decade of research, approaches to treat autoimmunity with PD-1 agonists still need to be more successful. To resolve this, new methods must be developed to augment PD-1 function beyond engaging the receptor.
View Article and Find Full Text PDFThe immunome of mobilized peripheral blood stem cells is predictive of long-term outcomes and therapy-related myeloid neoplasms in patients with multiple myeloma undergoing autologous stem cell transplant.
Blood Cancer J
September 2023
Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- Upfront autologous stem cell transplant (ASCT) is the standard treatment for newly diagnosed multiple myeloma (MM) patients, but relapse and therapy-related myeloid neoplasms (t-MN) are common and typically lead to poor outcomes.
- A study involving 54 MM patients undergoing ASCT found that abnormal myeloid progenitors and immune effector cell (IEC) profiles in their peripheral blood stem cells (PBSCs) were linked to a higher risk of relapse and worse survival rates.
- The results indicate that these abnormal cell characteristics were present before ASCT, suggesting that early detection could help in tailoring future treatment strategies to improve patient outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!