Synthesis and Biological Activities of Some Metal Complexes of Peptides: A Review.

BioTech (Basel)

Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, University of Plovdiv, "Tzar Assen" Str. 24, 4000 Plovdiv, Bulgaria.

Published: April 2024

AI Article Synopsis

  • - Peptides, whether natural or synthetic, have diverse applications including drug delivery, tumor treatment, and use in biocatalysts, highlighting their significance in various fields of research.
  • - Research emphasizes the importance of therapeutic peptides with properties like anticancer and antimicrobial effects, while also identifying crucial metal elements that interact with biological systems and contribute to health issues such as neurodegenerative diseases.
  • - The investigation into metal-bound peptides and proteins, along with the use of various analytical techniques, offers insights for future studies and strategies in the area of peptide-chelated metals and their potential biotechnological applications.

Article Abstract

Peptides, both natural and synthetic, are well suited for a wide range of purposes and offer versatile applications in different fields such as biocatalysts, injectable hydrogels, tumor treatment, and drug delivery. The research of the better part of the cited papers was conducted using various database platforms such as MetalPDB. The rising prominence of therapeutic peptides encompasses anticancer, antiviral, antimicrobial, and anti-neurodegenerative properties. The metals Na, K, Mg, Ca, Fe, Mn, Co, Cu, Zn, and Mo are ten of the twenty elements that are considered essential for life. Crucial for understanding the biological role of metals is the exploration of metal-bound proteins and peptides. Aside from essential metals, there are other non-essential metals that also interact biologically, exhibiting either therapeutic or toxic effects. Irregularities in metal binding contribute to diseases like Alzheimer's, neurodegenerative disorders, Wilson's, and Menkes disease. Certain metal complexes have potential applications as radiopharmaceuticals. The examination of these complexes was achieved by preforming UV-Vis, IR, EPR, NMR spectroscopy, and X-ray analysis. This summary, although unable to cover all of the studies in the field, offers a review of the ongoing experimentation and is a basis for new ideas, as well as strategies to explore and gain knowledge from the extensive realm of peptide-chelated metals and biotechnologies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11036290PMC
http://dx.doi.org/10.3390/biotech13020009DOI Listing

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