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LC-MS/MS-Based Concurrent Quantification of Cannabidiol and Melatonin in Mouse Plasma to Elucidate Complex PK Interactions.
Pharmaceutics
November 2024
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
This study aimed to develop a quantitative analytical method for the simultaneous determination of cannabidiol (CBD) and melatonin (MT) in mouse plasma using the protein precipitation method coupled with LC-MS/MS. Additionally, this study sought to investigate the impact of CBD on the pharmacokinetics of MT in mice using this method. Mouse plasma samples were precipitated with acetonitrile and analyzed using a Kromasil 100-5-C8 (2.
View Article and Find Full Text PDF[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.].
Adv Gerontol
January 2025
Belgorod State National Research University, 85 build. 10 Pobedy str., Belgorod 308015, Russian Federation, e-mail:
Article Synopsis
- The review summarizes long-term research by the Saint-Petersburg Institute of Bioregulation and Gerontology on the biological activity of peptide bioregulators and compares findings from domestic and international studies.
- Russian scientists have taken the lead in using buccal epithelium as a diagnostic marker for age-related diseases, highlighting their significant contributions in this field.
- The research reveals that peptides from the epiphysis can enhance melatonin secretion and influence circadian rhythms in the elderly by regulating gene expression and reducing harmful protein synthesis, suggesting their potential as therapeutic agents for age-related issues.
Preclinical Evidence for a Drug-Drug Interaction Between Cannabinol and Melatonin.
Basic Clin Pharmacol Toxicol
January 2025
Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
The worldwide legalization of medicinal cannabis has led to an increased use of products made by commercial operators. These products often contain minor cannabinoids such as cannabinol (CBN) which are advertised to improve sleep. Products are also available in which CBN is combined with conventional therapies, with a common product containing both CBN and the widely used sleep-aid melatonin.
View Article and Find Full Text PDF3-Month Melatonin Supplementation to Reduce Brain Oxidative Stress and Improve Sleep in Mild Cognitive Impairment: A Randomised Controlled Feasibility Trial.
J Pineal Res
November 2024
Healthy Brain Ageing Program, Brain and Mind Centre, School of Psychology, The University of Sydney, Sydney, New South Wales, Australia.
Melatonin has multiple proposed therapeutic benefits including antioxidant properties, circadian rhythm synchronisation and sleep promotion. Since these areas are also recognised risk factors for dementia, melatonin has been hypothesised to slow cognitive decline in older adults. Participants with Mild Cognitive Impairment (MCI) were recruited from the community for a 12-week randomised placebo-controlled parallel, feasibility trial of 25 mg oral melatonin nightly.
View Article and Find Full Text PDFExploring the DPP IV inhibitory potential: molecular docking and dynamic simulations of pyridine-3-carboxylic acid and pyrrolidine-2-carboxylic acid analogs.
J Biomol Struct Dyn
December 2024
Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Science and Research, affiliated to SPPU, Pune, India.
Diabetes mellitus remains a global challenge, with Type 2 Diabetes Mellitus (T2DM) prevalence increasing from 4% to 6.4% in the past 30 years. Presently oral hypoglycaemic agents like GLP-1 agonists, biguanides, sulphonylureas, glinides, and thiazolidinediones are employed in clinical practice.
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