While prior studies have examined the effects of urban form on transportation carbon emissions, the exploration of nonlinear influences remains limited. This study presents an approach that transcends simple quantification of urban form's impact on transportation carbon emissions by also identifying the threshold range over which urban form variables exert their influence. Using 282 Chinese prefecture-level cities as the sample, this study employs gradient boosting decision trees to identify the nonlinear effects and the relative importance of urban form factors on transportation carbon emissions. We find that urban form factors jointly account for 31.32 % of the predictive power in estimating transportation carbon emissions after controlling for transport facilities, socioeconomic, and demographic factors. Urban polycentricity and transportation carbon emissions generally exhibit an obvious and complex nonlinear relationship. In addition, polycentricity, urban dispersion, the number of (sub)centers, and population density all have clear threshold effects on transportation carbon emissions. We further identified their effective ranges to guide urban development and land use planning.
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http://dx.doi.org/10.1016/j.scitotenv.2024.172547 | DOI Listing |
Pharmaceutics
January 2025
Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak 38156-8-8349, Iran.
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. With drug targeting, conventional, biotechnological and gene-derived drugs target the body's organs, tissues, and cells that can be selectively transported to specific regions.
View Article and Find Full Text PDFNutrients
January 2025
Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Background/objectives: Chronic gut dysbiosis due to a high-fat diet (HFD) instigates cardiac remodeling and heart failure with preserved ejection fraction (HFpEF), in particular, kidney/volume-dependent HFpEF. Studies report that although mitochondrial ATP citrate lyase (ACLY) supports cardiac function, it decreases more in human HFpEF than HFrEF. Interestingly, ACLY synthesizes lipids and creates hyperlipidemia.
View Article and Find Full Text PDFMolecules
January 2025
Faculty of Science, Pavol Jozef Šafárik University in Košice, Park Angelinum 19, 040 01 Košice, Slovakia.
Hemoglobin is an oxygen-transport protein in red blood cells that interacts with multiple ligands, e.g., oxygen, carbon dioxide, carbon monoxide, and nitric oxide.
View Article and Find Full Text PDFMolecules
January 2025
Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming 650032, China.
The incorporation of reinforcing fillers into natural rubber latex (NR) to achieve superior elasticity and mechanical properties has been widely applied across various fields. However, the tendency of reinforcing fillers to agglomerate within NR limits their potential applications. In this study, multi-walled carbon nanotube (MWCNT)-silica (SiO)/NR composites were prepared using a solution blending method, aiming to enhance the performance of NR composites through the synergistic effects of dual-component fillers.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
College of Civil Engineering, Nanjing Forestry University, Nanjing 210037, China.
The global asphalt production growth rate exceeded 10% in the past decade, and over 90% of the world's road surfaces are generated from asphalt materials. Therefore, the issue of asphalt aging has been widely researched. In this study, the aging of asphalt thin films under various natural conditions was studied to prevent the distortion of indoor simulated aging and to prevent the extraction of asphalt samples from road surfaces from impacting the aged asphalt.
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