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Diagnosis, management, and outcomes of parechovirus infections in infants: an overview. | LitMetric

Diagnosis, management, and outcomes of parechovirus infections in infants: an overview.

J Clin Microbiol

Department of Pathology and Laboratory Medicine, Children's Mercy Hospital and Clinics, Kansas City, Missouri, USA.

Published: June 2024

AI Article Synopsis

Article Abstract

Parechovirus A (PeV-A) infections have been detected with increasing frequency in US infants under 6 months of age, leading to a Centers for Disease Control and Prevention (CDC) health advisory in July 2022. Clinicians are advised to consider PeV-A laboratory testing of blood and cerebrospinal fluid when infants present with unexplained fever, sepsis-like illness, or neurological issues. Clinical laboratories are encouraged to offer in-house molecular testing for PeV-A to avoid diagnostic delays, unnecessary use of antibiotics, and prolonged hospitalization of infants presenting with sepsis-like illness. While data are evolving on potential neurodevelopmental sequelae after PeV-A infant central nervous system infections, most infected infants return to baseline health for age. This review examines the PeV-A literature with a focus on PeV-A3, including aspects of epidemiology, clinical presentations/management, laboratory diagnostics, genotyping, and post-infectious sequelae related to PeV-A infections in infants.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237800PMC
http://dx.doi.org/10.1128/jcm.01139-23DOI Listing

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