AI Article Synopsis
- Dysfunctional sensory gating in anxiety disorders may be linked to issues with the inhibitory neurotransmitter GABA, as indicated by P50 event-related potentials (ERPs).
- A study with 30 healthy participants tested the effects of GABA agonists (lorazepam and baclofen) on auditory sensory gating and looked for correlations with self-reported anxiety levels.
- Results showed that lorazepam reduced sensory gating responses, while baclofen's effects correlated with trait anxiety, suggesting that GABA plays a role in sensory gating and anxiety regulation.
Article Abstract
Background: Dysfunctional sensory gating in anxiety disorders, indexed by the failure to inhibit the P50 event-related potential (ERP) to repeated stimuli, has been linked to deficits in the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).
Aims/methods: This study, conducted in 30 healthy volunteers, examined the acute effects of GABA (lorazepam: 1 mg) and GABA receptor (baclofen: 10 mg) agonists on P50 measures of auditory sensory gating within a paired-stimulus (S1-S2) paradigm and assessed changes in gating in relation to self-ratings of anxiety.
Results: Compared to placebo, lorazepam reduced ERP indices of sensory gating by attenuating response to S1. Although not directly impacting P50 inhibition, baclofen-induced changes in gating (relative to placebo) were negatively correlated with trait but not state anxiety.
Conclusions: These preliminary findings support the involvement of GABA in sensory gating and tentatively suggest a role for GABA receptor signaling in anxiety-associated gating dysregulation.
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| http://dx.doi.org/10.1177/02698811241246854 | DOI Listing |
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