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Variant Pseudocystic Desmoplastic Small Round Cell Tumor With Heterologous Mullerian Cysts.
Pediatr Dev Pathol
January 2025
Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University Medical Center, St. Louis, MO, USA.
A desmoplastic small round cell tumor (DSRCT) presented in a 13-year-old female with an acute abdomen due to torsion of a fallopian tube cyst. She was found to have an incidental 2 cm pedunculated, solid, and multicystic mass attached to the pelvic floor on laparoscopy. The neoplasm had a variably myxoid and spindle cell pattern with nests and cords of small cells, forming pseudocysts, and true cysts lined by ciliated epithelium which were PAX-8+ and ER+/PR+.
View Article and Find Full Text PDFAdults and Adolescents With Neuroblastoma: An Analysis of the National Cancer Database.
J Surg Oncol
January 2025
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background And Objectives: Neuroblastoma, the most common extracranial solid tumor in children, is rare in adults. This study compares patient characteristics, disease patterns, and treatments among adults, adolescents, and children with neuroblastoma.
Methods: We queried the National Cancer Database (2004-2019) for neuroblastoma cases.
Home Medication Regimen Complexity in Newly Diagnosed Pediatric Oncology Patients.
Cancer Nurs
January 2025
Author Affiliations: School of Nursing (Ms Skipper and Drs Rice and Landier), Institute for Cancer Outcomes and Survivorship, School of Medicine (Ms Skipper and Drs Wadhwa, York, Bhatia, and Landier), and Division of Pediatric Hematology/Oncology, Department of Pediatrics, School of Medicine (Drs Wadhwa, Bhatia, and Landier), University of Alabama at Birmingham.
Background: Parents of children newly diagnosed with cancer require specialized education to provide care for their child at home, including the management of complex medication regimens.
Objective: To assess the complexity of home medication regimens in a cohort of newly diagnosed pediatric oncology patients.
Methods: We inventoried and categorized all discharge medications for each patient and used the Medication Regimen Complexity Index (MRCI) to quantify the complexity of the prescribed medication regimens.
Prevention of Infections Among Pediatric Solid Organ Transplant Recipients With Asplenia or Hyposplenism.
Pediatr Transplant
February 2025
Department of Pediatrics, Division of Infectious Diseases, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Pediatric solid organ transplant (SOT) recipients with splenic dysfunction are at increased risk for infections, and tailored guidance on the management of asplenia/hyposplenism among SOT recipients is often lacking. The purpose of this article is to provide practice recommendations via a frequently asked questions (FAQs) format that focuses on three main domains: the identification of asplenia/hyposplenism among SOT recipients/candidates, prophylactic strategies for mitigating the risk of invasive disease associated with splenic dysfunction in the context of transplantation, and the provision of appropriate patient counseling on the risks associated with asplenia/hyposplenism. Answers to the FAQs are based on international expert opinion informed by practices for managing splenic dysfunction and associated data in other populations with asplenia.
View Article and Find Full Text PDFNo Vaccine, No Organ? Ethics of Vaccine Mandates for Pediatric Transplant.
Pediatr Transplant
February 2025
Departments of Health Humanities and Bioethics, Philosophy, Pediatrics, and Neurology, University of Rochester, Rochester, New York, USA.
Many transplant programs worldwide are likely to impose vaccine mandates for pediatric solid organ transplant candidates; some already do. Three potential benefits that advocates invoke to justify mandates are improved patient outcomes, efficient organ allocation, and contributions to community protection. We show that none of these benefits can justify mandates.
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