Urease and human glioblastoma (U87) cells growth inhibitory iridoid glycoside acetates from Linn.

The present study was undertaken on the chemical constituents of ethanol extract of aerial parts of Linn., and their determination of growth inhibitory activity against glioblastoma multiforme cell line (U87) and urease inhibitory activity. Six constituents were isolated including two new arbortristoside F tetraacetate () and arbortristoside G heptaacetate () and four known arborside A tetraacetate (), arborside C pentaacetate (), 6,7-di--acetyl-6-hydroxyloganin hexaacetate () and nyctanthoside heptaacetate () iridoid glycoside acetates. Their structures were elucidated using spectroscopic methods, including 1D and 2D NMR and mass analyses. Compounds and showed significant growth inhibition of U87 cell line (76.41 and 87.62% inhibition) respectively while , and showed moderate inhibition. and showed notable urease inhibition (IC = 17.2 ± 0.4 and 17.2 ± 0.7 µM) respectively, and IC of , and were 23.8 - 56.3 µM. Compound was inactive.