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Tailoring formulation for enhanced phage therapy in canine otitis externa: a cocktail approach targeting Pseudomonas aeruginosa and Staphylococcus pseudintermedius.
Vet Microbiol
December 2024
Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1, Gwanak-ro, Seoul 08826, Republic of Korea. Electronic address:
Canine otitis externa, characterized by the involvement of diverse bacterial species, notably Pseudomonas aeruginosa and Staphylococcus pseudintermedius, necessitates antibiotic administration as the primary therapeutic approach; however, prolonged treatment often precipitates antibiotic resistance. Therefore, the application of bacteriophages as antimicrobial agents has been of interest recently. However, phage therapy has limitations; its efficacy depends on the lytic capacity of the phage and the emergence of phage resistance, which can be overcome by using phage cocktails.
View Article and Find Full Text PDFLight microscopy is a practical tool for advancing biomedical research and diagnostics, offering invaluable insights into the cellular and subcellular structures of living organisms. However, diffraction and optical imperfections actively hinder the attainment of high-quality images. In recent years, there has been a growing interest in applying deep learning techniques to overcome these challenges in light microscopy imaging.
View Article and Find Full Text PDFChallenges to Students' Learning and Wellbeing During Placement Abroad: A Qualitative Study Using Rich Pictures.
Perspect Med Educ
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School of Health Professions Education (SHE), Faculty of Health, Medicine and Life sciences, Maastricht University, Maastricht, The Netherlands.
Introduction: Undergraduate healthcare students on placement abroad can experience challenges that affect their wellbeing, personal and professional development. These challenges may result in students taking a more peripheral role in workplace activities, which negatively impacts learning. We studied .
View Article and Find Full Text PDFSingle chain fragment variable, a new theranostic approach for cardiovascular diseases.
Front Immunol
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Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources, College of Life Science, Anhui Normal University, Wuhu, Anhui, China.
Cardiovascular diseases (CVDs) remain a significant global health challenge, leading to substantial morbidity and mortality. Despite recent advancements in CVD management, pharmaceutical treatments often suffer from poor pharmacokinetics and high toxicity. With the rapid progress of modern molecular biology and immunology, however, single-chain fragment variable (scFv) molecule engineering has emerged as a promising theranostic tool to offer specificity and versatility in targeting CVD-related antigens.
View Article and Find Full Text PDFThe Fallacy of Categorization in Urology: A Call for Continuous Thinking in the Era of Artificial Intelligence.
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Department of Urology, Jules Bordet Institute and Erasme Hospital, Hôpital Universitaire de Bruxelles, Brussels, Belgium. Electronic address:
Categorization of patients according to their characteristics may simplify decision-making, but it fails to account for the continuous nature of risk and individual variability. Artificial intelligence has the ability to handle more complex continuous data for more precise, individualized recommendations, but several challenges must be overcome to unlock this potential.
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