Metaplastic breast carcinoma (MBC) is a rare and aggressive subtype of breast cancer characterized by the presence of both epithelial and mesenchymal components within the tumor. Its clinical and radiological appearance is comparable to other types of breast cancer, but it grows rapidly. The diagnosis of metaplastic carcinoma is largely based on the epithelial origin of the cells confirmed by immunohistochemistry (IHC). Compared to invasive ductal carcinoma, metaplastic carcinoma has a worse overall survival rate. Any patient with a rapidly growing breast mass should be assessed with suspicion of sarcomatoid or metaplastic malignant neoplasm. We report this case due to its rarity and the complex nature of the disease.
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http://dx.doi.org/10.7759/cureus.56619 | DOI Listing |
Breast Cancer Res
December 2024
Department of Pathology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Background: Human mammary epithelial cell (HMEC) cultures encounter a stress-associated barrier termed stasis, during which most cells adopt a senescence-like phenotype. From these cultures, rare variants emerge from the basal epithelial population, re-initiating growth. Variants exhibit pre-malignant properties, including an aberrant epigenetic program that enables continued proliferation and acquisition of genetic changes.
View Article and Find Full Text PDFInt J Surg Pathol
December 2024
Breast Department, KK Women's and Children's Hospital, Singapore.
Fibromatosis-like metaplastic carcinoma (FLMC) is a rare subtype of metaplastic carcinoma of the breast. Diagnosing this entity poses significant challenges, particularly in core biopsies due to limited sampling and overlap with benign spindle cell lesions such as nodular fasciitis and fibromatosis. We present an example of FLMC in an asymptomatic middle-aged woman.
View Article and Find Full Text PDFBreast
December 2024
Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China. Electronic address:
Background: Metaplastic breast cancer (MBC) is a rare and highly aggressive histological subtype of breast cancer. There remains a significant lack of precise predictive models available for use in clinical practice.
Methods: This study utilized patient data from the SEER database (2010-2018) for data analysis.
Am J Dermatopathol
November 2024
Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT.
Int J Surg Pathol
December 2024
James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Secretory carcinoma is a rare breast tumor driven by fusion. It has characteristic morphologic features and identification of these tumors is critical as these patients may benefit from TRK inhibitors. Morphologic shift upon treatment has not been reported in secretory carcinoma or other -driven tumors.
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