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Development of a multi-epitope vaccine candidate to combat SARS-CoV-2 and dengue virus co-infection through an immunoinformatic approach.
Front Immunol
March 2025
Division of Metabolomics, Proteomics & Imaging facility, Regional Medical Research Centre, Indian Council of Medical Research (ICMR), Dibrugarh, Assam, India.
Background: Although the SARS-CoV-2 and dengue viruses seriously endanger human health, there is presently no vaccine that can stop a person from contracting both viruses at the same time. In this study, four antigens from SARS-CoV-2 and dengue virus were tested for immunogenicity, antigenicity, allergenicity, and toxicity and chosen to predict dominant T- and B-cell epitopes.
Methods: For designing a multi-epitope vaccine, the sequences were retrieved, and using bioinformatics and immunoinformatics, the physicochemical and immunological properties, as well as secondary structures, of the vaccine were predicted and studied.
Proanthocyanidin B2 alleviates LPS-induced RAW264.7 cellular inflammation and oxidative stress via PI3K/Akt/NFkB pathway.
Cytotechnology
April 2025
The Affiliated Stomatological Hospital, Jiangxi Medical College, Nanchang University, NO.688, Honggu North Road, Honggu Tan District, Nanchang City, 330038 Jiangxi Province China.
Periodontitis is a multifactorial chronic inflammatory infectious disease associated with systemic diseases. Proanthocyanidin B2 (PB2), a polyphenol, has been investigated to exhibit antioxidant, anti-inflammatory and anti-cancer pharmacological properties. PB2 has shown good efficacy in treating hepatocellular carcinoma, type 2 diabetes mellitus, and ulcerative colitis.
View Article and Find Full Text PDFNatural synthesis of β-glucan nanoparticles via microwave for breast cancer prevention: a study on oats-derived nanoparticles.
Nat Prod Res
March 2025
Department of Biochemistry, Indian Institute of Science, Bangalore, India.
This study investigates the antibacterial and cancer-preventive properties of β-glucan nanoparticles (GNP) synthesised from oats using microwave energy, sodium tripolyphosphate (TPP), and silver (Ag). UV-visible spectroscopy indicated a strong surface plasmon resonance peak between 220 and 250 nm for GNP. FTIR analysis identified a band at 609 cm, signifying β linkage and confirming the presence of β-glucans.
View Article and Find Full Text PDFPhysicochemical, Volatile Compound Profile, Antioxidant, and Cytotoxic Activities of Northeastern Thai Ethnic Ready-to-Serve Food Pastes Jaew Hon and Gang Om: A Comparative Study of Laboratory and Industrial Production Processes.
Foods
March 2025
Research Unit of Thai Food Innovation, Department of Food Technology and Nutrition, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham 44150, Thailand.
Northeastern Thai ethnic foods are celebrated for their health benefits yet remain largely underexplored. This study assessed the antioxidant and cytotoxic properties of two ready-to-eat pastes-Jaew Hon (JH) and Gang Om (GO)-produced using laboratory (LAB) and industrial original equipment manufacturer (OEM) methods. Evaluations were conducted using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), total phenolic content (TPC), and total flavonoid content (TFC) assays alongside the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for cytotoxicity.
View Article and Find Full Text PDFDevelopment of Bioactive Edible Film and Coating Obtained from sp. Extract Applied for Enhancing Shelf Life of Fresh Products.
Foods
February 2025
Scientific Equipment and Research Division, Kasetsart University Research and Development Institute (KURDI), Kasetsart University, Bangkok 10900, Thailand.
The growing interest in environmentally friendly food packaging has led to the development of bio-edible alternatives. This study developed novel, edible, active films and coatings to enhance the shelf life of fresh products. Crude bioactive algal extract (CBAE) was obtained from the ethanol extraction of sp.
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