AI Article Synopsis
- Medical tapes can cause skin damage upon removal, especially in individuals with fragile skin; this study compared the effects of silicone-based versus acrylate-based adhesive tapes on healthy volunteers.* -
- Conducted across two facilities, the study assessed adhesion, skin protein removal, water loss (TEWL), and inflammation markers after using four types of medical tapes.* -
- Results showed silicone tapes had better adhesion and caused less skin disruption compared to acrylate tapes, suggesting that silicone options might be preferred for minimizing skin damage.*
Article Abstract
Background: Medical tapes can lead to skin damage upon removal in susceptible patients with fragile skin and at higher risk of developing tissue injury.
Purpose: We compared the effect of medical tapes with silicone-based versus acrylate-based adhesives on the back or volar forearm stratum corneum using analytical techniques to assess skin condition and potential damage post product removal on 88 healthy volunteers.
Methods: Two studies were conducted in separate facilities (Study 1: 3M In-house Clinical Facility, St. Paul, Minnesota; Study 2: DermiCo, LLC, Broomall, Pennsylvania). Four commercially available tapes were the same in both studies, two for each type of adhesive. We evaluated adhesion to the skin, total proteins and corneocytes removed by the tapes, changes in transepidermal water loss (TEWL), and induction of the inflammatory cytokine interleukin-1 alpha (IL-1a).
Results: One of the silicone tapes displayed the strongest adhesion at 24 hours, and one of the acrylate tapes had the lowest adhesion, showing differences in performance within adhesive categories. The adhesion forces did not correlate with the amount of total protein or corneocytes removed. Silicone adhesives removed less total protein and corneocytes than acrylate adhesives. Silicone adhesives did not alter TEWL, whereas acrylate adhesives significantly raised TEWL. There were no differences in interleukin-1alpha induction.
Conclusion: The silicone adhesive tapes were less disruptive to the skin barrier than the acrylate adhesive tapes, even in healthy volunteers whose skin is not as fragile as what is observed in typical patients. This type of data could guide clinical product usage decisions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027027 | PMC |
| http://dx.doi.org/10.7759/cureus.56548 | DOI Listing |
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