Bevacizumab-Induced Cutaneous Lupus Erythematosus in a Patient With Metastatic Colon Carcinoma: A Case Report.

Cureus

Hematology and Medical Oncology, Allegheny Health Network, Pittsburgh, USA.

Published: March 2024

AI Article Synopsis

  • Bevacizumab is a cancer treatment that works by inhibiting vascular epidermal growth factor and is associated with side effects like hypertension and bleeding.
  • Rare skin reactions, such as exfoliative dermatitis, have been reported with this medication.
  • A specific case is presented where a patient with metastatic colon cancer developed cutaneous lupus likely caused by bevacizumab, which started to improve after stopping chemotherapy, highlighting the importance of prompt medical attention.

Article Abstract

Bevacizumab, an anti-vascular epidermal growth factor inhibitor, is approved for the treatment of various cancers. Hypertension, gastrointestinal perforation, bleeding manifestations, impaired wound healing, and cerebrovascular accidents are common side effects associated with the monoclonal antibody. Uncommon cutaneous reactions like exfoliative dermatitis associated with bevacizumab have been documented in the medical literature. We present an unusual case of bevacizumab-induced cutaneous lupus in a patient with metastatic colon cancer that started resolving after discontinuing chemotherapy. Timely intervention was key in preventing the progression of this chemotherapy-induced cutaneous lupus.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11028020PMC
http://dx.doi.org/10.7759/cureus.56559DOI Listing

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