Purpose: There is a need for valid and reliable clinical assessment tools to assess cardiorespiratory fitness (CRF) levels in adolescents with autism. Therefore, this study aimed to examine the concurrent validity and test-retest reliability of the Astrand-Rhyming Test (ART) in this population.
Materials And Methods: 45 adolescents with autism aged 12-18 years ( = 32 males, 14.47 ± 1.79 years) performed the ART twice (test-retest reliability) and completed a maximal cardiopulmonary exercise test (CPET) (concurrent validity). Reliability parameters included Pearson correlations, intraclass correlation coefficients (ICCs), standard error of measurements (SEM), minimal detectable changes (MDC), coefficients of variation, paired sample t-tests, linear regressions and Bland-Altman plots. The concurrent validity was evaluated with Pearson correlations, ICCs, paired sample t-tests, linear regressions and Bland-Altman plots.
Results: Strong test-retest reliability ( = 0.84-0.85, ICC = 0.84-0.85) was found for the ART, but the wide limits of agreement intervals suggest the presence of substantial variability. The large SEM (4.73-5.08 mL/kg/min) and MDC (13.20-14.07 mL/kg/min) values suggest lower absolute reliability. Moderate to strong levels of association ( = 0.74-0.75) and agreement (ICC = 0.59-0.66) were found between estimated (ART1) and measured (CPET) VO max levels, but significant systematic differences (5.71-8.82 mL/kg/min) were observed.
Conclusion: The ART is an accessible and promising method to monitor submaximal CRF levels over time but is less appropriate to estimate maximal CRF levels in this population.
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http://dx.doi.org/10.1080/09638288.2024.2340704 | DOI Listing |
J Clin Med
January 2025
Health, Physical Activity and Sports Technology (HEALTH-TECH), Department of General and Specific Didactics, Faculty of Education, University of Alicante, 03690 Alicante, Spain.
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View Article and Find Full Text PDFGenes (Basel)
January 2025
Division of Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.
A notion of the continuous production of amyloid-β (Aβ) via the proteolysis of Aβ-protein-precursor (AβPP) in Alzheimer's disease (AD)-affected neurons constitutes both a cornerstone and an article of faith in the Alzheimer's research field. The present Perspective challenges this assumption. It analyses the relevant empirical data and reaches an unexpected conclusion, namely that in AD-afflicted neurons, the production of AβPP-derived Aβ is either discontinued or severely suppressed, a concept that, if proven, would fundamentally change our understanding of the disease.
View Article and Find Full Text PDFSci Rep
January 2025
School of Marine Science and Technology, Northwestern Polytechnical University, Xi'an, 710072, People's Republic of China.
This study develops predictive models for Chinese female patients with VL utilizing machine learning techniques. The aim is to create an effective model that can assist in clinical diagnosis and treatment of vaginal relaxation, thereby enhancing women's pelvic floor health. In total, 1184 women with VL have been randomly selected and categorized into groups using the finger measurement method.
View Article and Find Full Text PDFJ Patient Rep Outcomes
January 2025
Lien Centre for Palliative Care, Duke-NUS Medical School, Singapore, Singapore.
Background: Rising number of children with complex medical conditions necessitate regular healthcare quality evaluation to achieve optimal outcomes. To address the need for a periodic and quick assessment of quality of care in serious childhood illnesses, we developed a short version of previously validated 45-item PaRental Experience with care for Children with serIOUS illnesses (PRECIOUS) measure.
Methodology: PRECIOUS was administered by parents of children living with serious illnesses at two time-points (baseline and two weeks) in an online survey.
Int J Sports Physiol Perform
January 2025
Department of Sport and Physical Activity, Faculty of Arts and Sciences, Edge Hill University, Ormskirk, United Kingdom.
Background: Practices to routinely monitor athletes are rapidly changing. With the concurrent exponential rise in wearable technologies and advanced data analysis, tracking training exposures and responses is widespread and more frequent in the athlete-coach decision-making process. Within this scenario, the concept of invisible monitoring emerged, which was initially vaguely defined as testing athletes without testing them.
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